Geschmack ist vorhersagbar: Mit FlavorMiner. FlavorMiner heißt das Tool, das IPB-Chemiker und Partner aus Kolumbien jüngst entwickelt haben. Das Programm kann, basierend auf maschinellem Lernen (KI), anhand der…
Seit Februar 2021 bietet Wolfgang Brandt, ehemaliger Leiter der Arbeitsgruppe Computerchemie am IPB, sein Citizen Science-Projekt zur Pilzbestimmung an. Dafür hat er in regelmäßigen Abständen öffentliche Vorträge zur Vielfalt…
In vitro studies with the ruthenium(II) and analogous iridium(III) complexes [Ru(η6- p-cymene)Cl2{Ph2PCH2CH2CH2S(O)xPh-κP}], [Ru(η6-p-cymene)Cl{Ph2PCH2CH2CH2S(O)xPh- κP,κS}][PF6] (1–4), [Ir(η5-C5Me5)Cl2{Ph2PCH2CH2CH2S(O)xPh-κP}] and [Ir(η5-C5Me5)Cl{Ph2 PCH2CH2CH2S(O)xPh-κP,κS}][PF6] (5–8; x = 0, 1) revealed the high selectivity toward the 8505C, A253, MCF-7, SW480 and 518A2 cancer cell lines. Thus, the cationic ruthenium complex 4 proved to be the most selective one. In case of the neutral and cationic ruthenium complexes 1–4 the caspase-dependent apoptotic cell death was proven as the main cause of the drug’s tumoricidal action on 8505C cell line.
Publikation
Bulatović, M. Z.; Maksimović-Ivanić, D.; Bensing, C.; Gómez-Ruiz, S.; Steinborn, D.; Schmidt, H.; Mojić, M.; Korać, A.; Golić, I.; Pérez-Quintanilla, D.; Momčilović, M.; Mijatović, S.; Kaluđerović, G. N.;Organozinn(IV)-beladenes mesoporöses SiO2 als biokompatible Strategie bei der KrebstherapieAngew. Chem.1266092-6097(2014)DOI: 10.1002/ange.201400763
Das große therapeutische Potenzial eines Organozinn(IV)‐beladenen nanostrukturierten SiO2 (SBA‐15pSn) wird am Beispiel der Rückbildung eines durch B16‐Zellen induzierten Melanoms bei syngenen C57BL/6‐Mäusen demonstriert. Neben Apoptose als grundlegendem Mechanismus der Antitumorwirkung einer Vielzahl von Chemotherapeutika ist der entscheidende Vorteil dieses mesoporösen zinnhaltigen Materials das Auslösen der Zelldifferenzierung – ein Effekt, der weder für metallbasierte Zytostatika noch für mesoporöse Materialien alleine bisher beobachtet wurde. Dieser nichtaggressive Wirkungsmechanismus ist hochwirksam gegen Tumorzellen aber im gewählten Konzentrationsbereich nichttoxisch für normales Gewebe. JNK‐unabhängige Apoptose (JNK: Jun amino‐terminal kinase), begleitet von der Bildung des melanozytenartigen nichtproliferativen Phänotyps der überlebenden Zellen demonstriert das außergewöhnliche Potenzial von SBA‐15pSn zur Unterdrückung von Tumorwachstum ohne eine unerwünschte kompensatorische Proliferation der erkrankten Zellen als Antwort auf den Zelltod in ihrer Nachbarschaft.
Publikation
Bulatović, M. Z.; Maksimović-Ivanić, D.; Bensing, C.; Gómez-Ruiz, S.; Steinborn, D.; Schmidt, H.; Mojić, M.; Korać, A.; Golić, I.; Pérez-Quintanilla, D.; Momčilović, M.; Mijatović, S.; Kaluđerović, G. N.;Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer TreatmentAngew. Chem. Int. Ed.535982-5987(2014)DOI: 10.1002/anie.201400763
The strong therapeutic potential of an organotin(IV) compound loaded in nanostructured silica (SBA‐15pSn) is demonstrated: B16 melanoma tumor growth in syngeneic C57BL/6 mice is almost completely abolished. In contrast to apoptosis as the basic mechanism of the anticancer action of numerous chemotherapeutics, the important advantage of this SBA‐15pSn mesoporous material is the induction of cell differentiation, an effect unknown for metal‐based drugs and nanomaterials alone. This non‐aggressive mode of drug action is highly efficient against cancer cells but is in the concentration range used nontoxic for normal tissue. JNK (Jun‐amino‐terminal kinase)‐independent apoptosis accompanied by the development of the melanocyte‐like nonproliferative phenotype of survived cells indicates the extraordinary potential of SBA‐15pSn to suppress tumor growth without undesirable compensatory proliferation of malignant cells in response to neighboring cell death.
Bis(benzylamine)diacetylplatinum(II) (3) reacted with 2-pyridyl-functionalized hydrazones and with diacetyl dihydrazone to yield diacetyl platinum(II) complexes [Pt(COMe)2(2-pyCRNNH2)] (R = H, 4a; Me, 4b; Ph, 4c) and [Pt(COMe)2(H2NNCMe–CMeNNH2)] (5). These complexes showed weak intramolecular N–H⋯O hydrogen bonds where the hydrazone and the acetyl ligand act as H donor and H acceptor, respectively. Using hydrazones 2-pyCRNNHR′ substituted with electron-withdrawing groups R′ resulted in complexes [Pt(COMe)2(2-pyCRNNHR′)] (R/R′ = H/C6H4-p-F, 6d; Me/C6H4-p-F, 6e; H/COMe, 7a; Me/COMe, 7b; H/COPh, 7c; Me/COPh, 7d; H/CO(C6H4-p-F), 7e; Me/CO(C6H4-p-F), 7f) with stronger intramolecular N–H⋯O hydrogen bonds. The isolation of the analogous phenylhydrazone complexes (R′ = Ph) failed on this way, but reactions of the 1D coordination polymer [{Pt(COMe)2}n] (2) with phenylhydrazones resulted in the formation of the desired complexes [Pt(COMe)2(2-pyCRNNHR′)] (R/R′ = H/Ph, 6a; Me/Ph, 6b; Ph/Ph, 6c; H/C6F5, 6f). The constitution of all complexes was unambiguously confirmed analytically, spectroscopically and, in part, by single-crystal X-ray diffraction analyses. Structural and NMR parameters gave evidence that the strength of the N–H⋯O hydrogen bond is increased in the order 5 ≈ 4a–c < 6a–e < 6f ≈ 7a–f. This goes parallel with an activation of the acetyl ligand, but in no case the reaction with amines resulted in the formation of iminoacetyl platinum(II) complexes as it was found in analogous oxime–diacetyl complexes [Pt(COMe)2(2-pyCRNOH)] which have stronger (even than in type 6f/7a–f complexes) intramolecular O–H⋯O hydrogen bonds.