Unser 10. Leibniz Plant Biochemistry Symposium am 7. und 8. Mai war ein großer Erfolg. Thematisch ging es in diesem Jahr um neue Methoden und Forschungsansätze der Naturstoffchemie. Die exzellenten Vorträge über Wirkstoffe…
Omanische Heilpflanze im Fokus der Phytochemie IPB-Wissenschaftler und Partner aus Dhofar haben jüngst die omanische Heilpflanze Terminalia dhofarica unter die phytochemische Lupe genommen. Die Pflanze ist reich an…
Geschmack ist vorhersagbar: Mit FlavorMiner. FlavorMiner heißt das Tool, das IPB-Chemiker und Partner aus Kolumbien jüngst entwickelt haben. Das Programm kann, basierend auf maschinellem Lernen (KI), anhand der…
Gray, C. J.; Weissenborn, M. J.; Eyers, C. E.; Flitsch, S. L.;Enzymatic reactions on immobilised substratesChem. Soc. Rev.426378-6405(2013)DOI: 10.1039/C3CS60018A
This review gives an overview of enzymatic reactions that have been conducted on substrates attached to solid surfaces. Such biochemical reactions have become more important with the drive to miniaturisation and automation in chemistry, biology and medicine. Technical aspects such as choice of solid surface and analytical methods are discussed and examples of enzyme reactions that have been successful on these surfaces are provided.
Publikation
Mihály, T.; Bette, M.; Mihály, B.; Schmidt, J.; Schmidt, H.; Steinborn, D.;Synthesis, structure and characterization of adenine-based aminocarbene complexes of platinum(II)J. Organomet. Chem.73957-62(2013)DOI: 10.1016/j.jorganchem.2013.04.030
The reaction of the dinuclear platina-β-diketone [Pt2{(COMe)2H}2(μ-Cl)2] (1) with two equivalents of adenine and its methylated derivatives N6-R,9-R′Ade–H resulted in adenine-based aminocarbene platinum(II) complexes [Pt(COMe)Cl{CMe(N6-R,9-R′Ade–H)-κC,κN}] (R/R′ = Me/Me, 2; H/Me, 3; H/H, 4) whose identities were confirmed by NMR and IR spectroscopies as well as by high-resolution mass spectrometric investigations. Single-crystal X-ray diffraction analyses of complexes 2 and 4·THF revealed relatively short Pt–C and N–C bonds in the aminocarbene–platinum units, which is in accord with a substantial double bond character of these bonds. The electronic structure of these complexes will be further confirmed by DFT calculations as also the course of reaction.
Publikation
Brauch, S.; van Berkel, S. S.; Westermann, B.;Higher-order multicomponent reactions: beyond four reactantsChem. Soc. Rev.424948-4962(2013)DOI: 10.1039/C3CS35505E
Multicomponent reactions (MCRs) are by far the most successful class of reactions leading to high structural diversity and molecular complexity through a single transformation. As part of the ongoing search for pharmacologically active lead structures, the obtained structural diversity allows for the fast exploration of a large chemical space. Not surprisingly, the development of MCRs, leading to new structural frameworks or serving as key transformations in the total synthesis of natural products, has expanded rapidly over the last few decades. To date a multitude of new three- and four-component reactions have already been described; however, examples of “higher-order” MCRs where five or even more components are combined in a single reaction vessel are remarkably scarce. This tutorial review aims to critically describe the developments achieved in recent years, charting the ideas, challenges, and milestone reactions that were essential for the progress of this field.