Unser 10. Leibniz Plant Biochemistry Symposium am 7. und 8. Mai war ein großer Erfolg. Thematisch ging es in diesem Jahr um neue Methoden und Forschungsansätze der Naturstoffchemie. Die exzellenten Vorträge über Wirkstoffe…
Omanische Heilpflanze im Fokus der Phytochemie IPB-Wissenschaftler und Partner aus Dhofar haben jüngst die omanische Heilpflanze Terminalia dhofarica unter die phytochemische Lupe genommen. Die Pflanze ist reich an…
Geschmack ist vorhersagbar: Mit FlavorMiner. FlavorMiner heißt das Tool, das IPB-Chemiker und Partner aus Kolumbien jüngst entwickelt haben. Das Programm kann, basierend auf maschinellem Lernen (KI), anhand der…
Isonitrile meta/para’-functionalized biaryl ethers can serve as key building blocks for the highly efficient and diverse one step production of natural product inspired peptide/peptoid macrocycles, thereby forming up to 54-membered rings with eight or even sixteen new bonds. Aliphatic diamine and diacid tethers give access to two different classes of biaryl ether cyclopeptoids, either with exo/endo or exclusively endo dipeptidic moieties.
Publikation
Paixão, M. W.; de Godoi, M.; Rhoden, C. R.; Westermann, B.; Wessjohann, L. A.; Lüdtke, D. S.; Braga, A. L.;The application of chiral, non-racemic N-alkylephedrine and N,N-dialkylnorephedrine as ligands for the enantioselective aryl transfer reaction to aldehydesJ. Mol. Catal. A261120-124(2007)DOI: 10.1016/j.molcata.2006.07.076
The catalytic enantioselective arylation of several aldehydes using arylboronic acids as the source of transferable aryl groups is described; the reaction is found to proceed in excellent yields and high enantioselectivities (up to 96% ee) in the presence of a chiral amino alcohol derived from ephedrines and congeners.
Publikation
Kreye, O.; Westermann, B.; Wessjohann, L.;A Stable, Convertible Isonitrile as a Formic Acid Carbanion [-COOH] Equivalent and Its Application in Multicomponent ReactionsSynlett20073188-3192(2007)DOI: 10.1055/s-2007-990912
The application of 2-(2,2-dimethoxyethyl) phenyl isonitrile in Ugi, Passerini, and Ugi-Smiles reactions is described. The simple transformation to highly activated indolyl amides allows functional-group conversion of the isonitrile moiety into a variety of carboxylic acid derivatives, overall acting as a neutral, nucleophilic COOH equivalent.
Publikation
Abbas, M.; Westermann, B.; Voelter, W.;Synthesis of 3,4-disaccharides from pyranosides and furanosides monomers, a novel class of potential bioactive disaccharidesARKIVOC2007329(2007)DOI: 10.3998/ark.5550190.0008.729
A new class of synthetically and pharmacologically important disaccharides containing epoxide moieties were synthesized from pyranoside and furanoside monomers in good to excellent yields. The scope and limitations for the formation of the linkage were evaluated.