Geschmack ist vorhersagbar: Mit FlavorMiner. FlavorMiner heißt das Tool, das IPB-Chemiker und Partner aus Kolumbien jüngst entwickelt haben. Das Programm kann, basierend auf maschinellem Lernen (KI), anhand der…
Seit Februar 2021 bietet Wolfgang Brandt, ehemaliger Leiter der Arbeitsgruppe Computerchemie am IPB, sein Citizen Science-Projekt zur Pilzbestimmung an. Dafür hat er in regelmäßigen Abständen öffentliche Vorträge zur Vielfalt…
Wessjohann, L. A.; Voigt, B.; Rivera, D. G.;Diversity Oriented One-Pot Synthesis of Complex Macrocycles: Very Large Steroid-Peptoid Hybrids from Multiple Multicomponent Reactions Including Bifunctional Building BlocksAngew. Chem. Int. Ed.444785-4790(2005)DOI: 10.1002/anie.200500019
Up to 16 new bonds connect 12 building blocks to form 54‐membered macrocycles (46‐membered example shown) in a one‐pot procedure combining bifunctional components with multicomponent reactions. The large rings are not made of repetitive subunits and form an ideal basis for the fast construction of libraries of chiral host molecules.
Publikation
Gao, W.; Loeser, R.; Raschke, M.; Dessoy, M. A.; Fulhorst, M.; Alpermann, H.; Wessjohann, L. A.; Zenk, M. H.;(E)-4-Hydroxy-3-methylbut-2-enyl Diphosphate: An Intermediate in the Formation of Terpenoids in Plant ChromoplastsAngew. Chem. Int. Ed.412604-2607(2002)DOI: 10.1002/1521-3773(20020715)41:14<2604::AID-ANIE2604>3.0.CO;2-S
The missing link in the new deoxyxylulose phosphate metabolic pathway leading to the biosynthesis of plant terpenoids has been identified. The intermediate between the cyclic diphosphate 1 and the basic isoprenoid building blocks dimethylallyl diphosphate and isopentenyl diphosphate has been shown for the first time to be (E )‐4‐hydroxy‐3‐methylbut‐2‐enyl diphosphate (2 ) by incorporation of tritium‐labeled 2 into phytoene.
Enzymes in search of a function, for polyphenol oxidases (PPOs), described as such, this situation has changed recently. A tyrosinase is involved in betacyanin biosynthesis in common portulaca (see picture) and red beet, and a chalcone‐specific PPO is responsible for the formation of aurones in yellow snapdragon flowers.
Antitumor agents possibly better than taxol might be drived from the epothilones (depicted on the right), which likewise bind to microtubules. The epothilones, which were discovered by Höfle et al. and Reichenbach et al., are easier to synthesize and more soluble in polar solvents than taxol. The results of in vivo activity studies are now eagerly awaited. The exceptional importance of these new tubulin stabilizers is reflected in the race for synthetic approaches to these compounds that has already led to the first total syntheses and several partial solutions.