Geschmack ist vorhersagbar: Mit FlavorMiner. FlavorMiner heißt das Tool, das IPB-Chemiker und Partner aus Kolumbien jüngst entwickelt haben. Das Programm kann, basierend auf maschinellem Lernen (KI), anhand der…
Seit Februar 2021 bietet Wolfgang Brandt, ehemaliger Leiter der Arbeitsgruppe Computerchemie am IPB, sein Citizen Science-Projekt zur Pilzbestimmung an. Dafür hat er in regelmäßigen Abständen öffentliche Vorträge zur Vielfalt…
Horbach, R.; Navarro-Quesada, A. R.; Knogge, W.; Deising, H. B.;When and how to kill a plant cell: Infection strategies of plant pathogenic fungiJ. Plant Physiol.16851-62(2011)DOI: 10.1016/j.jplph.2010.06.014
Fungi cause severe diseases on a broad range of crop and ornamental plants, leading to significant economical losses. Plant pathogenic fungi exhibit a huge variability in their mode of infection, differentiation and function of infection structures and nutritional strategy. In this review, advances in understanding mechanisms of biotrophy, necrotrophy and hemibiotrophic lifestyles are described. Special emphasis is given to the biotrophy-necrotrophy switch of hemibiotrophic pathogens, and to biosynthesis, chemical diversity and mode of action of various fungal toxins produced during the infection process.
Publikation
Braga, A. L.; Wessjohann, L. A.; Taube, P. S.; Galetto, F. Z.; de Andrade, F. M.;Straightforward Method for the Synthesis of Selenocysteine and Selenocystine Derivatives from L-Serine Methyl EsterSynthesis20103131-3137(2010)DOI: 10.1055/s-0030-1258188
A set of selenoamino acids has been efficiently synthesized under smooth conditions by a simple, flexible and modular strategy. In this method, O-mesylated l-serine methyl ester is generated in situ and directly substituted with various selenolate anions to afford selenocysteine, selenolanthionine, and selenocystine derivatives in good yields. Also, a tellurocysteine derivative can be obtained by this method.
Publikation
Braga, A. L.; Paixão, M. W.; Westermann, B.; Schneider, P. H.; Wessjohann, L. A.;Acceleration of Arylzinc Formation and Its Enantioselective Addition to Aldehydes by Microwave Irradiation and Aziridine-2-methanol CatalystsJ. Org. Chem.732879-2882(2008)DOI: 10.1021/jo702413n
The formation and 2-amino alcohol catalyzed addition of arylzinc reagents from and with boronic acids, respectively, is drastically accelerated to a few minutes under microwave irradiation without loss of enantioselectivity (up to 98% ee). Of the amino acid derived catalysts tested, the conformationally restricted bulky substituted aziridine-2-methanols derived from serine show the best overall performance in the formation of diarylmethanols.
Publikation
Paixão, M. W.; de Godoi, M.; Rhoden, C. R.; Westermann, B.; Wessjohann, L. A.; Lüdtke, D. S.; Braga, A. L.;The application of chiral, non-racemic N-alkylephedrine and N,N-dialkylnorephedrine as ligands for the enantioselective aryl transfer reaction to aldehydesJ. Mol. Catal. A261120-124(2007)DOI: 10.1016/j.molcata.2006.07.076
The catalytic enantioselective arylation of several aldehydes using arylboronic acids as the source of transferable aryl groups is described; the reaction is found to proceed in excellent yields and high enantioselectivities (up to 96% ee) in the presence of a chiral amino alcohol derived from ephedrines and congeners.