Unser 10. Leibniz Plant Biochemistry Symposium am 7. und 8. Mai war ein großer Erfolg. Thematisch ging es in diesem Jahr um neue Methoden und Forschungsansätze der Naturstoffchemie. Die exzellenten Vorträge über Wirkstoffe…
Omanische Heilpflanze im Fokus der Phytochemie IPB-Wissenschaftler und Partner aus Dhofar haben jüngst die omanische Heilpflanze Terminalia dhofarica unter die phytochemische Lupe genommen. Die Pflanze ist reich an…
Geschmack ist vorhersagbar: Mit FlavorMiner. FlavorMiner heißt das Tool, das IPB-Chemiker und Partner aus Kolumbien jüngst entwickelt haben. Das Programm kann, basierend auf maschinellem Lernen (KI), anhand der…
Wender, P. A.; Badham, N. F.; Conway, S. P.; Floreancig, P. E.; Glass, T. E.; Houze, J. B.; Krauss, N. E.; Lee, D.; Marquess, D. G.; McGrane, P. L.; Meng, W.; Mucciaro, T. P.; Mühlebach, M.; Natchus, M. G.; Ohkuma, T.; Peschke, B.; Rawlins, D. B.; Shuker, A. J.; Sutton, J. C.; Taylor, R. E.; Tomooka, K.; Wessjohann, L. A.;The Pinene Path to TaxanesACS Sym. Ser.583326-339(1995)ISBN:9780841215078DOI: 10.1021/bk-1995-0583.ch024
Taxol is a recent and striking example of the continuing impact of natural products chemistry on science and human health and a reminder of the significant return that is realized through investment in basic research. First isolated in the sixties from the bark of the Pacific Yew by chemists Wall, Wani, and their colleagues working in collaboration with the National Cancer Institute (1), taxol was found to possess a novel polycyclic structure (1) punctuated by a central eight-membered ring. Interest in the chemotherapeutic potential of this compound was stimulated by early cytotoxicity studies and greatly amplified by the subsequent proposal by Horwitz and coworkers that taxol operates through a new molecular mode of action involving the facilitated assembly and stabilization of microtubules (2). Clinical trials of taxol in the eighties proved to be sufficiently promising to warrant its subsequent approval for use in the treatment of ovarian cancer and, more