Geschmack ist vorhersagbar: Mit FlavorMiner. FlavorMiner heißt das Tool, das IPB-Chemiker und Partner aus Kolumbien jüngst entwickelt haben. Das Programm kann, basierend auf maschinellem Lernen (KI), anhand der…
Seit Februar 2021 bietet Wolfgang Brandt, ehemaliger Leiter der Arbeitsgruppe Computerchemie am IPB, sein Citizen Science-Projekt zur Pilzbestimmung an. Dafür hat er in regelmäßigen Abständen öffentliche Vorträge zur Vielfalt…
The Arabidopsis (Arabidopsis thaliana) calmodulin-binding
transcription activator3 (CAMTA3) is a repressor of immunity-related
genes but an activator of cold-induced or general stress-responsive
genes in plants. Post-transcriptional or posttranslational mechanisms
have been proposed to control CAMTA3 functions in different stress
responses. Here, we show that treatment with the bacterial flg22
elicitor induces CAMTA3 phosphorylation, which is accompanied by its
destabilization and nuclear export. Two flg22-responsive
mitogen-activated protein kinases (MAPKs), MPK3 and MPK6, directly
phosphorylate CAMTA3, with the phospho-sites contributing to CAMTA3
degradation and suppression of downstream target gene expression.
However, the flg22-induced nuclear export and phospho-mobility shift can
still be observed for the CAMTA3 phospho-null variant of the
MAPK-modified sites, suggesting additional flg22-responsive kinases
might be involved. Taken together, we propose that flg22-induced CAMTA3
depletion facilitates de-repression of downstream defense target genes,
which involves phosphorylation, increased protein turnover, and
nucleo-cytoplasmic trafficking.