Geschmack ist vorhersagbar: Mit FlavorMiner. FlavorMiner heißt das Tool, das IPB-Chemiker und Partner aus Kolumbien jüngst entwickelt haben. Das Programm kann, basierend auf maschinellem Lernen (KI), anhand der…
Seit Februar 2021 bietet Wolfgang Brandt, ehemaliger Leiter der Arbeitsgruppe Computerchemie am IPB, sein Citizen Science-Projekt zur Pilzbestimmung an. Dafür hat er in regelmäßigen Abständen öffentliche Vorträge zur Vielfalt…
Thuy, T. T.; Sung, T. V.; Franke, K.; Arnold, N.; Wessjohann, L.;Flavonone-C-glycosides from the seeds of Zizyphus Jujuba Mill var. Spinosa HuVietnam J. Chem.1-8(2007)
Rivera, D.; Wessjohann, L.;Synthesis of Novel Steroid-Peptoid Hybrid Macrocycles by Multiple Multicomponent Macrocyclizations Including Bifunctional Building Blocks (MiBs)Molecules121890-1899(2007)DOI: 10.3390/12081890
Two new groups of cholane-peptoid hybrid macrocycles were produced by implementing novel combinations of the MiB methodology. Steroid-based hybrid macrolactams including heterocycle and aryl moieties were obtained by utilizing cholanic dicarboxylic acids and diamines in a bidirectional double Ugi-Four-Component (Ugi-4CR) based macrocyclization protocol. Alternatively, N-substituted cyclocholamides were produced from a cholanic pseudo-amino acid by an Ugi-4CR-based cyclooligomerization approach. Both types of macrocycles are steroid-peptoid hybrid macrocycles containing exocyclic peptidic chains. These novel frameworks are a result of the use of bile acids bifunctionalized with carboxylic and amino functionalities as bifunctional building blocks of the Ugi-MiB approach.
Publikation
Ninh, P. T.; Anh, N. T. H.; Sung, T. V.; Wessjohann, L.;Studies on chemical constituents of the roots of Polygala sp.: II - Further phenylpropanoide sucrose estersVietnam J. Chem.45518-522(2007)
Anh, N. T. H.; Sung, T. V.; Arnold, N.; Wessjohann, L.;Chemical constituents of Zizyphus sativa Gaertn fruits. Part III - AlkaloidsVietnam J. Chem.45237-240(2007)
Two alkaloids have been isolated from Z. sativa fruits besides butane-2,3-diol and glycerol. The structures of alkaloids were established as stepharine and 1,2-dimethoxy,5,6,6a,7-tetrahydro-4H-dibenzo-quinoline by using MS, NMR spectroscopic data and by comparison with reported data.