Geschmack ist vorhersagbar: Mit FlavorMiner. FlavorMiner heißt das Tool, das IPB-Chemiker und Partner aus Kolumbien jüngst entwickelt haben. Das Programm kann, basierend auf maschinellem Lernen (KI), anhand der…
Seit Februar 2021 bietet Wolfgang Brandt, ehemaliger Leiter der Arbeitsgruppe Computerchemie am IPB, sein Citizen Science-Projekt zur Pilzbestimmung an. Dafür hat er in regelmäßigen Abständen öffentliche Vorträge zur Vielfalt…
Four new hygrophorones (1–4) together with the known hygrophorone B12 (5) have been isolated from fruiting bodies of the basidiomycete Hygrophorus abieticola Krieglst. ex Gröger & Bresinsky. Their structures were assigned on the basis of extensive one and two dimensional NMR spectroscopic analyses as well as ESI-HRMS measurements. Among these compounds, two previously undescribed hygrophorone types, named hygrophorone H12 (3) and 2,3-dihydrohygrophorone H12 (4), were identified. The absolute configuration of hygrophorone E12 (2) is suggested based on quantum chemical CD calculations, while a semisynthetic approach in conjunction with computational studies and analysis of NOE interactions allowed the stereochemical assignment of compounds 3 and 4. Additionally, semisynthetic derivatives of hygrophorone B12 (5) were generated by acetylation of the hydroxyl groups. The biological activity of the natural and semisynthetic hygrophorones was evaluated against phytopathogenic organisms, revealing that the α,β-unsaturated carbonyl functionality is likely to be an essential structural feature. Hygrophorone B12 (5) was identified as the most active compound, acting against both ascomycetous fungi and oomycetes.
Publikation
Anh, N. T. H.; Thuy, T. T.; Sung, T. V.; Dan, T. K.; Chinh, N. B.; Quang, N.; Franke, K.; Arnold, N.; Wessjohann, L.;Phytochemical study on the plants of the antidrug medication heantos 4: Part 3. Homoisoflavonoid, flavonoid and phenolic compoundsVietnam J. Chem.51358-362(2013)
Anh, N. T. H.; Thuy, T. T.; Sung, T. V.; Dan, T. K.; Chinh, N. B.; Quang, N.; Franke, K.; Arnold, N.; Wessjohann, L.;Phytochemical study on the plants of the antidrug medication heantos 4: Part 2. Terpenoid- and steroid compoundsVietnam J. Chem.51190-194(2013)
Thuy, T. T.; Anh, N. T. H.; Sung, T. V.; Dan, T. K.; Chinh, N. B.; Quang, N.; Franke, K.; Arnold, N.; Wessjohann, L.;Phytochemical study on the plants of the antidrug medication heantos 4: Part 4. Phthalides, fatty acids, oligosaccharide esters and miscellaneous compoundsVietnam J. Chem.51546-550(2013)