Omanische Heilpflanze im Fokus der Phytochemie IPB-Wissenschaftler und Partner aus Dhofar haben jüngst die omanische Heilpflanze Terminalia dhofarica unter die phytochemische Lupe genommen. Die Pflanze ist reich an…
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Baumert, A.; Schmidt, J.; Gröger, D.;Synthesis and mass spectral analysis of coenzyme a thioesters of anthranilic acid and its N-methyl derivative involved in acridone alkaloid biosynthesisPhytochem. Anal.4165-170(1993)DOI: 10.1002/pca.2800040406
Coenzyme A thioesters of anthranilic acid and N‐methylanthranilic acid were synthesized. The corresponding N‐hydroxysuccinimidyl esters proved to be useful as activated intermediates to prepare anthraniloyl‐CoA and N‐methylanthraniloyl‐CoA. These compounds were characterized by positive and negative ion liquid secondary ion mass spectrometry. Acridone synthase from suspension cultures of Ruta graveolens catalyses the condensation of N‐methylanthraniloyl‐CoA and malonyl‐CoA. The reaction product 1,3‐dihydroxy‐N‐methylacridone was directly identified after the extraction of the assay mixture by electron impact mass spectrometry and capillary gas chromatography.