- Ergebnisse als:
- Druckansicht
- Endnote (RIS)
- BibTeX
- Tabelle: CSV | HTML
Publikation
Publikation
Publikation
Bücher und Buchkapitel
Leitbild und Forschungsprofil
Molekulare Signalverarbeitung
Natur- und Wirkstoffchemie
Biochemie pflanzlicher Interaktionen
Stoffwechsel- und Zellbiologie
Unabhängige Nachwuchsgruppen
Program Center MetaCom
Publikationen
Gute Wissenschaftliche Praxis
Forschungsförderung
Netzwerke und Verbundprojekte
Symposien und Kolloquien
Alumni-Forschungsgruppen
Publikationen
Publikation
The synthesis and chemistry of the novel reagents and stereochemically defined taxane A-ring building blocks 7e–9e are described, providing the basis for the solution to problems previously encountered in the development of syntheses of taxol and its analogs based on pinene.
Publikation
From the methanol extract of the root bark of Discaria febrifuga Mart., in addition to the already described alkaloid, a new peptide alkaloid discarine-L has been isolated and its structure elucidated. This alkaloid differs from most of the known 14-membered peptide alkaloids by a 2-hydroxy-2-phenethylamine residue.
Publikation
Enol ethers are reacted with mercaptanes to give the corresponding O/S- or S/S-acetals in medium to high yield. Either product can be formed selectively depending on the acid catalyst and the reaction time applied.
Bücher und Buchkapitel
Taxol is a recent and striking example of the continuing impact of natural products chemistry on science and human health and a reminder of the significant return that is realized through investment in basic research. First isolated in the sixties from the bark of the Pacific Yew by chemists Wall, Wani, and their colleagues working in collaboration with the National Cancer Institute (1), taxol was found to possess a novel polycyclic structure (1) punctuated by a central eight-membered ring. Interest in the chemotherapeutic potential of this compound was stimulated by early cytotoxicity studies and greatly amplified by the subsequent proposal by Horwitz and coworkers that taxol operates through a new molecular mode of action involving the facilitated assembly and stabilization of microtubules (2). Clinical trials of taxol in the eighties proved to be sufficiently promising to warrant its subsequent approval for use in the treatment of ovarian cancer and, more