Dem IPB wird erneut ein beispielhaftes Handeln im Sinne einer chancengleichheitsorientierten Personal- und Organisationspolitik bescheinigt. Das Institut erhält zum 6. Mal in Folge das TOTAL E-QUALITY…
Die Plant Science Student Conference (PSSC) wird seit 20 Jahren im jährlichen Wechsel von Studierenden der beiden Leibniz-Institute IPK und IPB organisiert. Im Interview erläutern Christina Wäsch…
Four new antibiotics were isolated from a fermentation broth of Steptomyces lydicus (strain HKI0343). The 13‐membered‐ring peptides (see formula, XY: CH2NH, CHNH; R1, R2: H, OH) are cyclized through a lactone function at serine and also contain the nonproteinogenic amino acid piperazic acid (or a derivative thereof). The peptides show promising activity against various mycobacteria without being cytotoxic.
Publikation
Dömling, A.; Beck, B.; Eichelberger, U.; Sakamuri, S.; Menon, S.; Chen, Q.-Z.; Lu, Y.; Wessjohann, L. A.;Total Synthesis of Tubulysin U and VAngew. Chem. Int. Ed.457235-7239(2006)DOI: 10.1002/anie.200601259
Tubulysins are among the most potent cytotoxic agents known. Now the first total synthesis of some members has been achieved by utilizing a rapid three‐component reaction for the synthesis of the unusual central thiazole amino acid tubuvaline (see scheme; Boc=tert ‐butoxycarbonyl, Ac=acetyl), thereby opening new perspectives for anticancer drug development.