Dem IPB wird erneut ein beispielhaftes Handeln im Sinne einer chancengleichheitsorientierten Personal- und Organisationspolitik bescheinigt. Das Institut erhält zum 6. Mal in Folge das TOTAL E-QUALITY…
Die Plant Science Student Conference (PSSC) wird seit 20 Jahren im jährlichen Wechsel von Studierenden der beiden Leibniz-Institute IPK und IPB organisiert. Im Interview erläutern Christina Wäsch…
Neves Filho, R. A. W.; Brauer, M. C. N.; Palm-Forster, M. A. T.; de Oliveira, R. N.; Wessjohann, L. A.;Patented Catalysts for the Synthesis and Biological Applications of Dihydropyrimidinones: Recent Advances of the Biginelli ReactionRecent Pat. Catal.151-73(2012)DOI: 10.2174/2211548X11201010051
The acid-catalyzed and thermal multicomponent cyclocondensation between an aldehyde, a beta-keto ester and urea to generate dihydropyrimidinones (DHPMs) is one of the best studied multicomponent reactions in organic synthesis. It is frequently employed in the synthesis of natural products and biologically active compounds. After several years under academic development, this reaction drew the attention of researchers in the chemical and pharmaceutical industry. This critical review is focused on the development and applications of the Biginelli three component reaction (B-3CR) patented in the last three decades.