Dem IPB wird erneut ein beispielhaftes Handeln im Sinne einer chancengleichheitsorientierten Personal- und Organisationspolitik bescheinigt. Das Institut erhält zum 6. Mal in Folge das TOTAL E-QUALITY…
Die Plant Science Student Conference (PSSC) wird seit 20 Jahren im jährlichen Wechsel von Studierenden der beiden Leibniz-Institute IPK und IPB organisiert. Im Interview erläutern Christina Wäsch…
Scheid, G.; Kuit, W.; Ruijter, E.; Orru, R.; Henke, E.; Bornscheuer, U.; Wessjohann, L.;A New Route to Protected Acyloins and Their Enzymatic Resolution with LipasesEur. J. Org. Chem.20041063-1074(2004)DOI: 10.1002/ejoc.200300338
A series of 16 different 3‐acyloxy methyl ketones, the acyloin acetates and butyrates (±)‐5 , was synthesised by a straightforward new method through alkylation of tert‐butyl 2‐acyloxyacetoacetates 3 , followed by chemoselective dealkoxycarbonylation of the tert‐butyloxycarbonyl group in the presence of other ester groups. Subsequent hydrolysis of (±)‐5 can be achieved with base to give racemic acyloins 6 , or with lipase catalysis to afford the corresponding non‐racemic acyloins (S )‐6 . The remaining (R )‐acyloin esters 5 can be racemised and resubjected to the procedure, or hydrolysed chemically. The kinetic resolution with two of the six tested enzymes, CAL‐B and BCL (PS) lipase, proceeded selectively [enantiomeric ratio (E ) values between 50 and > 200] and most of the acyloins (S )‐6 were obtained in very high enantiomeric excesses (up to > 99% ee ).