Dem IPB wird erneut ein beispielhaftes Handeln im Sinne einer chancengleichheitsorientierten Personal- und Organisationspolitik bescheinigt. Das Institut erhält zum 6. Mal in Folge das TOTAL E-QUALITY…
Die Plant Science Student Conference (PSSC) wird seit 20 Jahren im jährlichen Wechsel von Studierenden der beiden Leibniz-Institute IPK und IPB organisiert. Im Interview erläutern Christina Wäsch…
Fobofou, S. A. T.; Franke, K.; Brandt, W.; Manzin, A.; Madeddu, S.; Serreli, G.; Sanna, G.; Wessjohann, L. A.;Bichromonol, a dimeric coumarin with anti-HIV activity from the stem bark of Hypericum roeperianumNat. Prod. Res.371947-1953(2023)DOI: 10.1080/14786419.2022.2110094
Infectious diseases caused by viruses like HIV and SARS-COV-2 (COVID-19) pose serious public health threats. In search for new antiviral small molecules from chemically underexplored Hypericum species, a previously undescribed atropisomeric C8-C8’ linked dimeric coumarin named bichromonol (1) was isolated from the stem bark of Hypericum roeperianum. The structure was elucidated by MS data and NMR spectroscopy. The absolute configuration at the biaryl axis was determined by comparing the experimental ECD spectrum with those calculated for the respective atropisomers. Bichromonol was tested in cell-based assays for cytotoxicity against MT-4 (CC50 ¼ 54 mM) cells and anti-HIV activity in infected MT-4 cells. It exhibits significant activity at EC50 ¼ 6.6–12.0 mM against HIV-1 wild type and its clinically relevant mutant strains. Especially, against the resistant variants A17 and EFVR, bichromonol is more effective than the commercial drug nevirapine and might thus have potential to serve as a new anti-HIV lead.
Publikation
Agzamova, M. A.; Mamadalieva, N. Z.; Mamadalieva, N.; Porzel, A.; Hussain, H.; Dube, M.; Franke, K.; Janibekov, A.; Wessjohann, L. A.;Lehmanniaside, a new cycloartane triterpene glycoside from Astragalus lehmannianusNat. Prod. Res.37354-359(2023)DOI: 10.1080/14786419.2021.1969563
Chemical investigation of the aerial parts of Astragalus lehmannianus
Bunge (Leguminosae) led to the isolation and identification of a new
cycloartane triterpene glycoside – lehmanniaside (2\'-O-acetyl-3-β-O-D-xylopyranosyl-3β,6α,16β,24α-tetrahydroxy-20,25-epoxycycloartane).
Its structure was elucidated by means of spectroscopic analysis (HR-MS,
1D and 2D NMR). Bioassays showed that lehmanniaside exhibits weak
anthelmintic, antifungal, and cytotoxic activities.