Dem IPB wird erneut ein beispielhaftes Handeln im Sinne einer chancengleichheitsorientierten Personal- und Organisationspolitik bescheinigt. Das Institut erhält zum 6. Mal in Folge das TOTAL E-QUALITY…
Die Plant Science Student Conference (PSSC) wird seit 20 Jahren im jährlichen Wechsel von Studierenden der beiden Leibniz-Institute IPK und IPB organisiert. Im Interview erläutern Christina Wäsch…
Gulyas-Fekete, G.; Boluda, C. J.; Westermann, B.; Wessjohann, L. A.;Anti-Friedel-Crafts-Type Substitution To Form Biaryl LinkagesSynthesis453038-3043(2013)DOI: 10.1055/s-0033-1339682
The ipso-substitution of one (or two) hydroxy groups of phloroglucinol with arene nucleophiles (e.g., o-xylene, tetralin, biphenyl) can be achieved easily under Friedel–Crafts-type conditions with or without the use of organic solvents affording a variety of 3,5-dihydroxybiphenyls (57–89% yields). The new method has significant practical advantages compared to classical biaryl-coupling routes.
Publikation
Wouters, A. D.; Bessa, A. B.; Sachini, M.; Wessjohann, L. A.; Lüdtke, D. S.;Boron-Zinc Exchange in The Diastereoselective Arylation of Sugar-Based Aldehydes: Stereoselective Synthesis of (+)-7-epi-Goniofufurone and AnaloguesSynthesis452222-2233(2013)DOI: 10.1055/s-0033-1339285
The substrate-controlled diastereoselective arylation of chiral aldehydes readily available from carbohydrates is described, using the boron–zinc exchange reaction to generate the transferable aryl groups. The methodology developed was applied to the total synthesis of the styryllactone (+)-7-epi-goniofufurone and analogues thereof.