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Heterocycle chemistry has traditionally relied on solution-phase synthesis as technological platform to discover and produce bioactive scaffolds. With the advent of solid-phase synthesis (SPS) at the end of last century, combinatorial approaches using on-resin procedures were applied to create skeletal and appendage diversity in heterocyclic compounds. Multicomponent reactions (MCRs) were part of that endeavor for developing solid-phase protocols capable to accelerate drug discovery. This chapter highlights methodological aspects of the implementation of on-resin MCRs to produce heterocycle compounds. Different name reactions, synthetic strategies, and solid supports are analyzed with a critical view hoping to encourage the new generation of chemists to adapt the more recent multicomponent – especially catalytic – processes to the SPS technology.