A novel type of tetrahydroisoquinoline alkaloid, antidesmone (1), was isolated from Antidesma membranaceum Müll. Arg.. The structure of 1 was determined to be (5S)-1-hydroxy-4-methoxy-3-methyl-5-octyl-5,6,7,8-tetrahydroisoquinolin-8-one by spectroscopic methods (MS, 1H, 13C 2D NMR, CD) and chemical derivatisation. The absolute (S)-configuration was determined by quantumchemical calculation of CD spectra.Antidesmone (1), a novel type of tetrahydroisoquinoline alkaloid, was isolated from Antidesma membranaceum Müll. Arg. The structure of 1 was determined to be (5S)-1-hydroxy-4-methyl-5-octyl-5,6,7,8-tetrahydroisoquinolin-8-one.

A novel type of tetrahydroisoquinoline alkaloid, antidesmone (1), was isolated from Antidesma membranaceum Müll. Arg.. The structure of 1 was determined to be (5S)-1-hydroxy-4-methoxy-3-methyl-5-octyl-5,6,7,8-tetrahydroisoquinolin-8-one by spectroscopic methods (MS, 1H, 13C 2D NMR, CD) and chemical derivatisation. The absolute (S)-configuration was determined by quantumchemical calculation of CD spectra.Antidesmone (1), a novel type of tetrahydroisoquinoline alkaloid, was isolated from Antidesma membranaceum Müll. Arg. The structure of 1 was determined to be (5S)-1-hydroxy-4-methyl-5-octyl-5,6,7,8-tetrahydroisoquinolin-8-one.

A novel type of tetrahydroisoquinoline alkaloid, antidesmone (1), was isolated from Antidesma membranaceum Müll. Arg.. The structure of 1 was determined to be (5S)-1-hydroxy-4-methoxy-3-methyl-5-octyl-5,6,7,8-tetrahydroisoquinolin-8-one by spectroscopic methods (MS, 1H, 13C 2D NMR, CD) and chemical derivatisation. The absolute (S)-configuration was determined by quantumchemical calculation of CD spectra.Antidesmone (1), a novel type of tetrahydroisoquinoline alkaloid, was isolated from Antidesma membranaceum Müll. Arg. The structure of 1 was determined to be (5S)-1-hydroxy-4-methyl-5-octyl-5,6,7,8-tetrahydroisoquinolin-8-one.