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IPB Newsletter | April 2025
Understanding Plants!

The IPB Video
Molecular Signal Processing

Prof. Dr. Steffen Abel
How plants stand their ground.
Bioorganic Chemistry

Prof. Dr. Ludger Wessjohann
The chemistry of nature - basis for active compounds for human and plant health.
Biochemistry of Plant Interactions

Prof. Dr. Tina Romeis
Interactions in, of and with plants.
Cell and Metabolic Biology

Prof. Dr. Alain Tissier
Secondary but never unimportant - the biological functions of plant secondary metabolites.
Independent Junior Research Group

Dr. Mariana Schuster

News

The Plant Science Student Conference (PSSC) has been organised by students from the two Leibniz institutes, IPK and IPB, every year for the last 20 years. In this interview, Christina Wäsch (IPK) and Carolin Apel (IPB)…

Over 600 guests came to the IPB on July 4 for the Long Night of Sciences to learn lots of new things and put their knowledge to the test at our science quiz course. This year, our program was aimed equally at children and…

Our 10th Leibniz Plant Biochemistry Symposium on May 7 and 8 was a great success. This year's theme was new methods and research approaches in natural product chemistry. The excellent presentations on active substances and…

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Technical Assistant or Laboratory Technician (m/f/d) (15/2025)

Date: 2025-07-25 Reference Number: 15/2025

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Date: 2025-07-11 Reference Number: 14/2025

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Preprints

Buhl, J.; Klemm, S.; Kölling, M.; Ruhnow, F.; Ihling, C.; Tüting, C.; Dahiya, P.; Patzsch, J.; Colin, L.; Stamm, G.; Sinz, A.; Kastritis, P. L.; Persson, S.; Bürstenbinder, K.; IQD2 recruits KLCR1 to the membrane-microtubule nexus to promote cytoskeletal mechano-responsiveness in leaf epidermis pavement cells bioRxiv (2024) DOI: 10.1101/2024.10.01.615909

Plant cells experience a variety of mechanical stresses from both internal and external sources, including turgor pressure, mechanical strains arising from heterogeneous growth between neighboring cells, and environmental factors like touch from soil, rain, or wind [1,2]. These stresses serve as signals at the cell-, tissue- and organismal level to coordinate plant growth during development and stress responses [3]. In plants, the physical cell wall-plasma membrane-microtubule continuum is proposed to be integral in transducing mechanical signals from the exterior to intracellular components [4–6]. Cortical microtubules (CMTs) rapidly reorient in response to mechanical stress to align with the maximal tensile stress direction [7,8]. Several studies proposed that CMTs themselves may act as stress sensors; the precise mechanisms involved in the regulation of CMTs and the modes of sensing, however, are still not clearly understood. Here, we show that IQD2 and KLCR1 are enriched at CMTs in proximity to the plasma membrane. IQD2, which is a bona fide microtubule-associated protein, promotes microtubule localization of KLCR1. By combining cross-linking mass spectrometry (XL-MS) and computational modeling with structure-function studies, we present first experimental insights into the composition and structure of IQD2-KLCR1 complexes. Further, we demonstrate that the IQD2-KLCR1 module is a positive regulator of microtubule mechano-responses in pavement cells. Collectively, our work identifies the IQD2-KLCR1 module as novel regulator of mechanostress-mediated CMT reorientation and provides a framework for future mechanistic studies aimed at a functional dissection of mechanotransduction at the plasma membrane-CMT interface during growth and plant morphogenesis.HighlightsIQD2 and KLCR1 localize to the plasma membrane-microtubule nexusIQD2 is required for efficient microtubule targeting of KLCR1in plantaIQD2 physically interacts with KLCR1 and microtubulesThe IQD2-KLCR1 module promotes mechano-stress induced microtubule reorganization

Preprints

Balcke, G.; Saoud, M.; Grau, J.; Rennert, R.; Mueller, T.; Yousefi, M.; Davari, M. D.; Hause, B.; Csuk, R.; Rashan, L.; Grosse, I.; Tissier, A.; Wessjohann, L.; Machine learning-based metabolic pattern recognition predicts mode of action for anti-cancer drug candidates Research Square (2024) DOI: 10.21203/rs.3.rs-3494185/v1

Preprints

Arndt, H.; Bachurski, M.; Yuanxiang, P.; Franke, K.; Wessjohann, L. A.; Kreutz, M. R.; Grochowska, K. M.; A screen of plant-based natural products revealed that quercetin prevents amyloid-β uptake in astrocytes as well as resulting astrogliosis and synaptic dysfunction Research Square (2024) DOI: 10.21203/rs.3.rs-4155455/v1

Printed publications

Farag, M. A.; Saied, D. B.; Afifi, S. M.; Kunzmann, A.; Wessjohann, L. A.; Westphal, H.; Kühnhold, H.; Stuhr, M.; Metabolic responses of sea anemone and jellyfish to temperature and UV bleaching: Insights into stress adaptation using LCMS-based metabolomics, molecular networking and chemometrics J. Adv. Res. (2024) DOI: 10.1016/j.jare.2024.10.007

Introduction: Climate change poses various threats to marine life, particularly in shallow tropical waters. Objective: The impact of increased temperature and ultraviolet (UV) exposure on two photosymbiotic cnidarians, a common bubble-tip anemone and an upside-down jellyfish, was investigated. Methods: To illustrate the response of aquatic organisms, the metabolomes of unstressed Entacmaea quadricolor and Cassiopea andromeda were compared for detailed metabolite profiling. UHPLC-MS cou-pled with chemometrics and GNPS molecular networking was employed for sample classification and identification of markers unique to stress responses in each organism. Results: Several compounds with bioactive functions, including peptides and terpenoids, were reported for the first time in both organisms, viz. cyclic tetraglutamate, campestriene, and ceramide aminoethyl phosphonate (CEAP d18:2/16:0). Both anemone and jellyfish were subjected to either elevated UV-B light intensity up to 6.6 KJ m-2 or increased temperatures (28°C, 30°C, 32°C, and 34°C) over 4 days. Phospholipids, steroids, and ceramides emerged as chief markers of both types of stress, as revealed by the multivariate data analysis. Lysophosphatidylcholine (LPC 16:0), LPC (18:0/0:0), and echinoclasterol sulfate appeared as markers in both UV and thermal stress models of the anemone, whereas methyl/pro-pyl cholestane-hexa-ol were discriminatory in the UV stress model only. In the case of jellyfish, nonpolar glycosyl ceramide GlcCer (d14:1/28:6) served as a marker for UV stress, whereas polar peptides were ele-vated in the thermal stress model. Interestingly, both models of jellyfish share a phospholipid, lysophos-phatidylethanolamine (LPE 20:4), as a distinctive marker for stress, reported to be associated indirectly with the activity of innate immune response within other photosymbiotic Cnidaria such as corals and appears to be a fundamental stress response in marine organisms. Conclusion: This study presents several bioinformatic tools for the first time in two cnidarian organisms to provide not only a broader coverage of their metabolome but also broader insights into cnidarian bleaching in response to different stressors, i.e., heat and UV light, by comparing their effects in anemone versus jellyfish.

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IPB Newsletter | April 2025

Understanding Plants!

Molecular Signal Processing

Bioorganic Chemistry

Biochemistry of Plant Interactions

Cell and Metabolic Biology

Independent Junior Research Group

News

PSSC: Success for the ‘Iron Lady’

Hands-on science and a big quiz marathon at the Long Night of Sciences

Well-attended symposium

Job vacancies

Technical Assistant or Laboratory Technician (m/f/d) (15/2025)

PhD position in (bio)chemistry (m/f/d) (14/2025)

PhD in Machine Learning for Enzyme Design (m/f/d)

Publications

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