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Molecular Signal Processing
Bioorganic Chemistry
Biochemistry of Plant Interactions
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Isonitrile meta/para’-functionalized biaryl ethers can serve as key building blocks for the highly efficient and diverse one step production of natural product inspired peptide/peptoid macrocycles, thereby forming up to 54-membered rings with eight or even sixteen new bonds. Aliphatic diamine and diacid tethers give access to two different classes of biaryl ether cyclopeptoids, either with exo/endo or exclusively endo dipeptidic moieties.