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Books and chapters
Books and chapters
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Molecular Signal Processing
Bioorganic Chemistry
Biochemistry of Plant Interactions
Cell and Metabolic Biology
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Books and chapters
Salicylic acid (SA) is an important signalling molecule in the defence response of plants against microbial pathogens. Plants are sessile and have to cope with environmental challenges without the ability to evade them actively. Responding in an appropriate manner upon pathogen attack is indispensable for their survival.
Books and chapters
Software engeneering today provides tools which minimize the need for manual coding of the typical components of an application, such as database, frontend and web application. Visual modelling brings together users and developers, and allows quick and direct communication about the topic. In the metabolomics community data models and XML formats for data interchange such as mzData are currently emerging. Using these standards as a show case, we present an infrastructure to support the use of these data standards and the process of getting there.
Books and chapters
Probabilistic latent semantic indexing (PLSI) represents documents of a collection as mixture proportions of latent topics, which are learned from the collection by an expectation maximization (EM) algorithm. New documents or queries need to be folded into the latent topic space by a simplified version of the EM-algorithm. During PLSI- Folding-in of a new document, the topic mixtures of the known documents are ignored. This may lead to a suboptimal model of the extended collection. Our new approach incorporates the topic mixtures of the known documents in a Bayesian way during folding- in. That knowledge is modeled as prior distribution over the topic simplex using a kernel density estimate of Dirichlet kernels. We demonstrate the advantages of the new Bayesian folding-in using real text data.
Books and chapters
"Naturstoffchemie" vermittelt Kenntnisse über die universellen Grundbausteine der Organismen (z.B. Aminosäuren, Peptide, Proteine etc.) über essenzielle biologisch aktive Verbindungen (z.B. Vitamine, Coenzyme, intrazelluläre Regulationsstoffe) über ausgewählte sekundäre Naturstoffe (z.B. Alkaloide, Antibiotika, isoprenoide Verbindungen). Insbesondere Naturstoffe und deren Abwandlungsprodukte mit bemerkenswerter biologischer Aktivität wurden bei der Auswahl berücksichtigt. Außerdemfinden sich die wichtigsten Synthese- und Abwandlungsmethoden typischer Vertreter. Struktur, chemische und physikochemische Eigenschaften sowie biologische Wirkungen wurden besonders herausgearbeitet.
Books and chapters
Mass spectrometry is the work-horse technology of the emerging field of metabolomics. Community-wide accepted data models and XML formats for data interchange such as mzData are currently in development. The information contained in these models is sufficient to create applications and databases in a model driven architecture (MDA). This allows to (re-)create the necessary code basis and backend database with minimal manual coding. We present an infrastructure to support the use of these data standards. It uses the Eclipse framework to generate Java objects, XML input/output, database persistence and a user-friendly editor for both the XML files and database content. A prototype of a Web frontend has been created to view, verify and upload to such a repository
Books and chapters
This chapter presents an overview about the immunocytochemical techniques using in the model legume Medicago truncatula. After a short introduction into the basics of immunocytochemistry, detailed protocols that can be used to perform immunolabelling on light, confocal and electron microscopical level are listed. These protocols are successfully applied in the author’s laboratories to obtain information about the localization of various proteins in a range of tissues from Medicago truncatula. Depending on facilities to perform sectioning and the microscopical equipment, modifications might be required to suit individual demands. Therefore, please use these protocols as a starting point and adjust them after consulting experienced personnel at your local facilities.