One of the most powerful methods for structural elucidation is nuclear magnetic resonance spectroscopy (NMR spectroscopy). This involves determining the number and type of atoms, their bonds and their three-dimensional arrangement in space. The most frequently measured nuclei are 1H, 13C, 15N, 31P and 19F. 2D experiments in which information about linkage (HSQC, HMBC, COSY, TOCSY) or the spatial proximity of atoms (NOESY, ROESY) is obtained are particularly important for the structural elucidation of small molecules. Depending on the problem, the range of methods can also be significantly expanded.

Contact:  Dr. Pauline Stark