Role of mannosyltransferase ALG12 for MAMP receptor integrity
Changes in cellular calcium levels are one of the earliest signaling events in plants exposed to pathogens or other exogenous factors. IPB scientists recently identified an Arabidopsis thaliana ‘changed calcium elevation 1’ (cce1) mutant with attenuated calcium response to the bacterial flagellin flg22 peptide and several other elicitors. The cce1 allele carries a mutation in the mannosyltrasferase ALG12 (Asparagine-Linked Glycosylation 12). With their study, the researchers show that ALG12 mediates N-glycosylation of MAMP receptors, thus responsible for their integrity and proper function in Calcium signaling.
Publication:
Trempel, F., Eschen‐Lippold, L., Bauer, N., Ranf, S., Westphal, L., Scheel, D. and Lee, J. (2020), A mutation in Asparagine‐Linked Glycosylation 12 (ALG12 ) leads to receptor misglycosylation and attenuated responses to multiple microbial elicitors. FEBS Lett. Accepted Author Manuscript. doi:10.1002/1873-3468.13850
