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IPB Newsletter | April 2025
Understanding Plants!

The IPB Video
Molecular Signal Processing

Prof. Dr. Steffen Abel
How plants stand their ground.
Bioorganic Chemistry

Prof. Dr. Ludger Wessjohann
The chemistry of nature - basis for active compounds for human and plant health.
Biochemistry of Plant Interactions

Prof. Dr. Tina Romeis
Interactions in, of and with plants.
Cell and Metabolic Biology

Prof. Dr. Alain Tissier
Secondary but never unimportant - the biological functions of plant secondary metabolites.
Independent Junior Research Group

Dr. Mariana Schuster

New findings on OPDA: No signaling effect in the early wound response

The plant stress hormone jasmonic acid (JA) and its bioactive form jasmonoyl isoleucine (JA-Ile) play a central role in the…

The IPB has once again been recognized for its exemplary actions in terms of equal opportunity-oriented personnel and organizational policies and has received the TOTAL E-QUALITY certification for the…

The Plant Science Student Conference (PSSC) has been organised by students from the two Leibniz institutes, IPK and IPB, every year for the last 20 years. In this interview, Christina Wäsch (IPK) and…

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Synthetic Organic Chemist (m/f/d) (18/2025)

Date: 2025-08-19 Reference Number: 18/2025

PhD position in biology (m/f/d) (17/2025)

Date: 2025-08-08 Reference Number: 17/2025

PhD in Machine Learning for Enzyme Design (m/f/d)

Date: 2025-05-16 Reference Number: 11/2025

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Farag, M. A.; Saied, D. B.; Afifi, S. M.; Kunzmann, A.; Wessjohann, L. A.; Westphal, H.; Kühnhold, H.; Stuhr, M.; Metabolic responses of sea anemone and jellyfish to temperature and UV bleaching: Insights into stress adaptation using LCMS-based metabolomics, molecular networking and chemometrics J. Adv. Res. 74 255-268 (2025) DOI: 10.1016/j.jare.2024.10.007

Introduction: Climate change poses various threats to marine life, particularly in shallow tropical waters. Objective: The impact of increased temperature and ultraviolet (UV) exposure on two photosymbiotic cnidarians, a common bubble-tip anemone and an upside-down jellyfish, was investigated. Methods: To illustrate the response of aquatic organisms, the metabolomes of unstressed Entacmaea quadricolor and Cassiopea andromeda were compared for detailed metabolite profiling. UHPLC-MS cou-pled with chemometrics and GNPS molecular networking was employed for sample classification and identification of markers unique to stress responses in each organism. Results: Several compounds with bioactive functions, including peptides and terpenoids, were reported for the first time in both organisms, viz. cyclic tetraglutamate, campestriene, and ceramide aminoethyl phosphonate (CEAP d18:2/16:0). Both anemone and jellyfish were subjected to either elevated UV-B light intensity up to 6.6 KJ m-2 or increased temperatures (28°C, 30°C, 32°C, and 34°C) over 4 days. Phospholipids, steroids, and ceramides emerged as chief markers of both types of stress, as revealed by the multivariate data analysis. Lysophosphatidylcholine (LPC 16:0), LPC (18:0/0:0), and echinoclasterol sulfate appeared as markers in both UV and thermal stress models of the anemone, whereas methyl/pro-pyl cholestane-hexa-ol were discriminatory in the UV stress model only. In the case of jellyfish, nonpolar glycosyl ceramide GlcCer (d14:1/28:6) served as a marker for UV stress, whereas polar peptides were ele-vated in the thermal stress model. Interestingly, both models of jellyfish share a phospholipid, lysophos-phatidylethanolamine (LPE 20:4), as a distinctive marker for stress, reported to be associated indirectly with the activity of innate immune response within other photosymbiotic Cnidaria such as corals and appears to be a fundamental stress response in marine organisms. Conclusion: This study presents several bioinformatic tools for the first time in two cnidarian organisms to provide not only a broader coverage of their metabolome but also broader insights into cnidarian bleaching in response to different stressors, i.e., heat and UV light, by comparing their effects in anemone versus jellyfish.

IPB Newsletter | April 2025

Understanding Plants!

Molecular Signal Processing

Bioorganic Chemistry

Biochemistry of Plant Interactions

Cell and Metabolic Biology

Independent Junior Research Group

+++ News Ticker Science 183 +++ Phytohormones +++

New findings on OPDA: No signaling effect in the early wound response

IPB receives TOTAL E-QUALITY certification for the sixth time in a row

PSSC: Success for the ‘Iron Lady’

Synthetic Organic Chemist (m/f/d) (18/2025)

PhD position in biology (m/f/d) (17/2025)

PhD in Machine Learning for Enzyme Design (m/f/d)

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