The IPB has once again been recognized for its exemplary actions in terms of equal opportunity-oriented personnel and organizational policies and has received the TOTAL E-QUALITY certification for the…
The Plant Science Student Conference (PSSC) has been organised by students from the two Leibniz institutes, IPK and IPB, every year for the last 20 years. In this interview, Christina Wäsch (IPK) and…
Manurung, J.; Kappen, J.; Schnitzler, J.; Frolov, A.; Wessjohann, L. A.; Agusta, A.; Muellner-Riehl, A. N.; Franke, K.;Analysis of Unusual Sulfated Constituents and Anti-infective Properties of Two Indonesian Mangroves, Lumnitzera littorea and Lumnitzera racemosa (Combretaceae)Separations882(2021)DOI: 10.3390/separations8060082
Lumnitzera littorea and Lumnitzera racemosa are mangrove species distributed widely along the Indonesian coasts. Besides their ecological importance, both are of interest owing to their wealth of natural products, some of which constitute potential sources for medicinal applications. We aimed to discover and characterize new anti-infective compounds, based on population-level sampling of both species from across the Indonesian Archipelago. Root metabolites were investigated by TLC, hyphenated LC-MS/MS and isolation, the internal transcribed spacer (ITS) region of rDNA was used for genetic characterization. Phytochemical characterization of both species revealed an unusual diversity in sulfated constituents with 3,3’,4’-tri-O-methyl-ellagic acid 4-sulfate representing the major compound in most samples. None of these compounds was previously reported for mangroves. Chemophenetic comparison of L. racemosa populations from different localities provided evolutionary information, as supported by molecular phylogenetic evidence. Samples of both species from particular locations exhibited anti-bacterial potential (Southern Nias Island and East Java against Gram-negative bacteria, Halmahera and Ternate Island against Gram-positive bacteria). In conclusion, Lumnitzera roots from natural mangrove stands represent a promising source for sulfated ellagic acid derivatives and further sulfur containing plant metabolites with potential human health benefits.
Publications
Greff, A.; Porzel, A.; Schmidt, J.; Palfner, G.; Arnold, N.;Pigment pattern of the Chilean mushroom Dermocybe nahuelbutensis Garrido & E. HorakRec. Nat. Prod.11547-551(2017)DOI: 10.25135/rnp.69.17.01.027
Fruiting bodies of the Chilean mushroom Dermocybe nahuelbutenis Garrido & E. Horak (syn.: Cortinariusnahuelbutensis (Garrido & E. Horak) E. Valenz. & G. Moreno) were chemically investigated for the first time andafforded the new dimeric anthraqinone 7,7'-emodinphyscion (1) beside the know anthraquinones dermolutein (2),endocrocin (3), skyrin (4) and the dimeric pre-anthraquinone derivative flavomannin C (5). The chemotaxonomicsignificance of the pigments is discussed.
Publications
Alresly, Z.; Lindequist, U.; Lalk, M.; Porzel, A.; Arnold, N.; Wessjohann, L. A.;Bioactive Triterpenes from the Fungus Piptoporus betulinusRec. Nat. Prod.10103-108(2016)
Phytochemical investigation of the ethyl acetate extract of the fruiting bodies from the basidiomycete Piptoporus betulinus led to the isolation of a new bioactive lanostane triterpene identified as 3 b -acetoxy-16-hydroxy-24-oxo-5α-lanosta-8- ene-21-oic acid (1). In addition, ten known triterpenes, polyporenic acid A (5), polyporenic acid C (4), three derivatives of polyporenic acid A (8, 10, 11), betulinic acid (3), betulin (2), ergosterol peroxide (6), 9,11-dehydroergosterol peroxide (7), and fomefficinic acid (9), were also isolated from the fungus. All isolated compounds were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria as well as against a fungal strain. The new triterpene and some of the other compounds showed antimicrobial activity against Gram-positive bacteria.
Publications
Ali, N. A. A.; Wurster, M.; Arnold, N.; Lindequist, U.; Wessjohann, L.;Essential Oil Composition from Oleogum Resin of Soqotraen Commiphora kuaRec. Nat. Prod.270-75(2008)
The major constituents of the essential oil obtained by hydrodistillation from the oleogum resin of Commiphora kua Vollesen were identified by GC-MS. Sixteen constituents were detected from the essential oil, which constituted about (90.5%) of the total amount. Major constituents of the oil were α- cadinol (33.0%), g -cadinene (22.5%), d -cadinene (17.0%), isocaryophyllene (3.7%), allo-aromadendrene (2.8%), α-muurolene (2.7%), and α-humulene (2.4%). The Oil of Commiphora kua showed moderate antifungal activity against Cladosporium cucumerinum.