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IPB Newsletter | April 2025
Understanding Plants!

The IPB Video
Molecular Signal Processing

Prof. Dr. Steffen Abel
How plants stand their ground.
Bioorganic Chemistry

Prof. Dr. Ludger Wessjohann
The chemistry of nature - basis for active compounds for human and plant health.
Biochemistry of Plant Interactions

Prof. Dr. Tina Romeis
Interactions in, of and with plants.
Cell and Metabolic Biology

Prof. Dr. Alain Tissier
Secondary but never unimportant - the biological functions of plant secondary metabolites.
Independent Junior Research Group

Dr. Mariana Schuster

New findings on OPDA: No signaling effect in the early wound response

The plant stress hormone jasmonic acid (JA) and its bioactive form jasmonoyl isoleucine (JA-Ile) play a central role in the…

The IPB has once again been recognized for its exemplary actions in terms of equal opportunity-oriented personnel and organizational policies and has received the TOTAL E-QUALITY certification for the…

The Plant Science Student Conference (PSSC) has been organised by students from the two Leibniz institutes, IPK and IPB, every year for the last 20 years. In this interview, Christina Wäsch (IPK) and…

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Synthetic Organic Chemist (m/f/d) (18/2025)

Date: 2025-08-19 Reference Number: 18/2025

PhD position in biology (m/f/d) (17/2025)

Date: 2025-08-08 Reference Number: 17/2025

PhD in Machine Learning for Enzyme Design (m/f/d)

Date: 2025-05-16 Reference Number: 11/2025

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Publications

Brack, W.; Ait-Aissa, S.; Burgess, R. M.; Busch, W.; Creusot, N.; Di Paolo, C.; Escher, B. I.; Hewitt, L. M.; Hilscherova, K.; Hollender, J.; Hollert, H.; Jonker, W.; Kool, J.; Lamoree, M.; Muschket, M.; Neumann, S.; Rostkowski, P.; Ruttkies, C.; Schollee, J.; Schymanski, E. L.; Schulze, T.; Seiler, T.-B.; Tindall, A. J.; de Aragão Umbuzeiro, G.; Vrana, B.; Krauss, M.; Effect-directed analysis supporting monitoring of aquatic environments — An in-depth overview Sci. Total Environ. 544 1073-1118 (2016) DOI: 10.1016/j.scitotenv.2015.11.102

Publications

Altenburger, R.; Ait-Aissa, S.; Antczak, P.; Backhaus, T.; Barceló, D.; Seiler, T.-B.; Brion, F.; Busch, W.; Chipman, K.; López de Alda, M.; de Aragão Umbuzeiro, G.; Escher, B. I.; Falciani, F.; Faust, M.; Focks, A.; Hilscherova, K.; Hollender, J.; Hollert, H.; Jäger, F.; Jahnke, A.; Kortenkamp, A.; Krauss, M.; Lemkine, G. F.; Munthe, J.; Neumann, S.; Schymanski, E. L.; Scrimshaw, M.; Segner, H.; Slobodnik, J.; Smedes, F.; Kughathas, S.; Teodorovic, I.; Tindall, A. J.; Tollefsen, K. E.; Walz, K.-H.; Williams, T. D.; Van den Brink, P. J.; van Gils, J.; Vrana, B.; Zhang, X.; Brack, W.; Future water quality monitoring — Adapting tools to deal with mixtures of pollutants in water resource management Sci. Total Environ. 512-513 540-551 (2015) DOI: 10.1016/j.scitotenv.2014.12.057

Environmental quality monitoring of water resources is challenged with providing the basis for safeguarding the environment against adverse biological effects of anthropogenic chemical contamination from diffuse and point sources. While current regulatory efforts focus on monitoring and assessing a few legacy chemicals, many more anthropogenic chemicals can be detected simultaneously in our aquatic resources. However, exposure to chemical mixtures does not necessarily translate into adverse biological effects nor clearly shows whether mitigation measures are needed. Thus, the question which mixtures are present and which have associated combined effects becomes central for defining adequate monitoring and assessment strategies. Here we describe the vision of the international, EU-funded project SOLUTIONS, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects. First of all, multi-residue target and non-target screening techniques covering a broader range of anticipated chemicals co-occurring in the environment are being developed. By improving sensitivity and detection limits for known bioactive compounds of concern, new analytical chemistry data for multiple components can be obtained and used to characterise priority mixtures. This information on chemical occurrence will be used to predict mixture toxicity and to derive combined effect estimates suitable for advancing environmental quality standards. Secondly, bioanalytical tools will be explored to provide aggregate bioactivity measures integrating all components that produce common (adverse) outcomes even for mixtures of varying compositions. The ambition is to provide comprehensive arrays of effect-based tools and trait-based field observations that link multiple chemical exposures to various environmental protection goals more directly and to provide improved in situ observations for impact assessment of mixtures. Thirdly, effect-directed analysis (EDA) will be applied to identify major drivers of mixture toxicity. Refinements of EDA include the use of statistical approaches with monitoring information for guidance of experimental EDA studies. These three approaches will be explored using case studies at the Danube and Rhine river basins as well as rivers of the Iberian Peninsula. The synthesis of findings will be organised to provide guidance for future solution-oriented environmental monitoring and explore more systematic ways to assess mixture exposures and combination effects in future water quality monitoring.

IPB Newsletter | April 2025

Understanding Plants!

Molecular Signal Processing

Bioorganic Chemistry

Biochemistry of Plant Interactions

Cell and Metabolic Biology

Independent Junior Research Group

+++ News Ticker Science 183 +++ Phytohormones +++

New findings on OPDA: No signaling effect in the early wound response

IPB receives TOTAL E-QUALITY certification for the sixth time in a row

PSSC: Success for the ‘Iron Lady’

Synthetic Organic Chemist (m/f/d) (18/2025)

PhD position in biology (m/f/d) (17/2025)

PhD in Machine Learning for Enzyme Design (m/f/d)

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