The IPB has once again been recognized for its exemplary actions in terms of equal opportunity-oriented personnel and organizational policies and has received the TOTAL E-QUALITY certification for the…
The Plant Science Student Conference (PSSC) has been organised by students from the two Leibniz institutes, IPK and IPB, every year for the last 20 years. In this interview, Christina Wäsch (IPK) and…
Krohn, K.; Vidal, A.; Vitz, J.; Westermann, B.; Abbas, M.; Green, I.;First enantiospecific Baker–Venkataraman-rearrangements aiming at the total synthesis of chiral anthrapyran antibioticsTetrahedron: Asymmetry173051-3057(2006)DOI: 10.1016/j.tetasy.2006.11.017
The base-catalyzed acyl transfer (Baker–Venkataraman reaction) of chiral 2-acetyl-1-hydroxyanthraquionone esters 6 of 2-methylbutanoic acid or 11 of O-allyl lactic acid proceeds with virtually no racemization to ketides 7 and 12. The subsequent acid-catalyzed cyclization to the chiral anthra[1,2-b]pyran antibiotics such as (S)-1″-11-dideoxyespicufolin 8 or 13 also occurs with a very low racemization.