The IPB has once again been recognized for its exemplary actions in terms of equal opportunity-oriented personnel and organizational policies and has received the TOTAL E-QUALITY certification for the…
The Plant Science Student Conference (PSSC) has been organised by students from the two Leibniz institutes, IPK and IPB, every year for the last 20 years. In this interview, Christina Wäsch (IPK) and…
Wender, P. A.; Badham, N. F.; Conway, S. P.; Floreancig, P. E.; Glass, T. E.; Houze, J. B.; Krauss, N. E.; Lee, D.; Marquess, D. G.; McGrane, P. L.; Meng, W.; Mucciaro, T. P.; Mühlebach, M.; Natchus, M. G.; Ohkuma, T.; Peschke, B.; Rawlins, D. B.; Shuker, A. J.; Sutton, J. C.; Taylor, R. E.; Tomooka, K.; Wessjohann, L. A.;The Pinene Path to TaxanesACS Sym. Ser.583326-339(1995)ISBN:9780841215078DOI: 10.1021/bk-1995-0583.ch024
Taxol is a recent and striking example of the continuing impact of natural products chemistry on science and human health and a reminder of the significant return that is realized through investment in basic research. First isolated in the sixties from the bark of the Pacific Yew by chemists Wall, Wani, and their colleagues working in collaboration with the National Cancer Institute (1), taxol was found to possess a novel polycyclic structure (1) punctuated by a central eight-membered ring. Interest in the chemotherapeutic potential of this compound was stimulated by early cytotoxicity studies and greatly amplified by the subsequent proposal by Horwitz and coworkers that taxol operates through a new molecular mode of action involving the facilitated assembly and stabilization of microtubules (2). Clinical trials of taxol in the eighties proved to be sufficiently promising to warrant its subsequent approval for use in the treatment of ovarian cancer and, more