The IPB has once again been recognized for its exemplary actions in terms of equal opportunity-oriented personnel and organizational policies and has received the TOTAL E-QUALITY certification for the…
The Plant Science Student Conference (PSSC) has been organised by students from the two Leibniz institutes, IPK and IPB, every year for the last 20 years. In this interview, Christina Wäsch (IPK) and…
Kaluđerović, G. N.; Abbas, M.; Kautz, H. C.; Wadaan, M. A. M.; Lennicke, C.; Seliger, B.; Wessjohann, L. A.;Methionine and seleno-methionine type peptide and peptoid building blocks synthesized by five-component five-center reactionsChem. Commun.533777-3780(2017)DOI: 10.1039/C7CC00399D
A first example of 5-component 5-center reactions with isonitriles [Ugi-5CRs] is described. The extended Ugi type reactions involve selenoaldehydes as well as ammonia, both challenging reactants in multicomponent (MCR) systems, to generate methionine and Se-methionine moieties and derivatives as protected building blocks or for direct ligation in peptides or peptoids. The peptoid/peptide building blocks proved to be non-cytotoxic but increased the expression of genes encoding for stress protective selenoproteins (Gpx1).