TY - JOUR ID - 2386 TI - The chromium—Reformatsky reaction: Asymmetric synthesis of the aldol fragment of the cytotoxic epothilons from 3-(2-bromoacyl)-2-oxazolidinones JO - Tetrahedron Lett. PY - 1997 SP - 1363-1366 AU - Gabriel, T. AU - Wessjohann, L. AU - VL - 38 UR - DO - 10.1016/S0040-4039(96)02494-X AB - In a two step, one pot reaction of 4-benzyl oxazolidinone, 2-bromoacetyl halide, chromium dichloride and a suitable 3-oxo-aldehyde derivative the C1C6Me - fragment of epothilons is available in its correct oxidation state and enantiomeric form. Compared to common methods, the chromium-Reformatsky variation preferentially yields the opposite diastereomers and gives improved chemo- and diastereoselection. A2 - C1 - Bioorganic Chemistry ER -