TY - JOUR ID - 1304 TI - Anti-Friedel-Crafts-Type Substitution To Form Biaryl Linkages JO - Synthesis PY - 2013 SP - 3038-3043 AU - Gulyas-Fekete, G. AU - Boluda, C. J. AU - Westermann, B. AU - Wessjohann, L. A. AU - VL - 45 UR - DO - 10.1055/s-0033-1339682 AB - The ipso-substitution of one (or two) hydroxy groups of phloroglucinol with arene nucleophiles (e.g., o-xylene, tetralin, biphenyl) can be achieved easily under Friedel–Crafts-type conditions with or without the use of organic solvents affording a variety of 3,5-dihydroxybiphenyls (57–89% yields). The new method has significant practical advantages compared to classical biaryl-­coupling routes. A2 - C1 - Bioorganic Chemistry ER -