@Article{IPB-365,
author = {Mahor, D. and Cong, Z. and Weissenborn, M. J. and Hollmann, F. and Zhang, W.},
title = {{Valorization of small alkanes by biocatalytic oxyfunctionalization}},
year = {2022},
pages = {e202101116},
journal = {ChemSusChem},
doi = {10.1002/cssc.202101116},
url = {https://doi.org/10.1002/cssc.202101116},
volume = {15},
abstract = {The oxidation of alkanes into valuable chemical products is avital reaction in organic synthesis. This reaction, however, ischallenging, owing to the inertness of C−H bonds. Transitionmetal catalysts for C−H functionalization are frequently ex-plored. Despite chemical alternatives, nature has also evolvedpowerful oxidative enzymes (e.g., methane monooxygenases,cytochrome P450 oxygenases, peroxygenases) that are capableof transforming C−H bonds under very mild conditions, withonly the use of molecular oxygen or hydrogen peroxide aselectron acceptors. Although progress in alkane oxidation hasbeen reviewed extensively, little attention has been paid tosmall alkane oxidation. The latter holds great potential for themanufacture of chemicals. This Minireview provides a conciseoverview of the most relevant enzyme classes capable of smallalkanes (C}    
}