@Article{IPB-353, author = {Krajnović, T. and Pantelić, N. ?. and Wolf, K. and Eichhorn, T. and Maksimović-Ivanić, D. and Mijatović, S. and Wessjohann, L. A. and Kaluđerović, G. N.}, title = {{Anticancer potential of Xanthohumol and Isoxanthohumol loaded into SBA-15 mesoporous silica particles against B16F10 melanoma cells}}, year = {2022}, pages = {5028}, journal = {Materials}, doi = {10.3390/ma15145028}, url = {https://doi.org/10.3390/ma15145028}, volume = {15}, abstract = {Xanthohumol (XN) and isoxanthohumol (IXN), prenylated flavonoids from Humulus lupulus, have been shown to possess antitumor/cancerprotective, antioxidant, antiinflammatory, and antiangiogenic properties. In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by standard analytical methods. The anticancer potential of XN and IXN loaded into SBA-15 has been evaluated against malignant mouse melanoma B16F10 cells. When these cells were treated with SBA-15 containing xanthohumol, an increase of the activity correlated with a higher immobilization rate of XN was observed. Considering the amount of XN loaded into SBA-15 (calculated from TGA), an improved antitumor potential of XN was observed (IC50 = 10.8 ± 0.4 and 11.8 ± 0.5 µM for SBA-15|XN2 and SBA-15|XN3, respectively; vs. IC50 = 18.5 ± 1.5 µM for free XN). The main mechanism against tumor cells of immobilized XN includes inhibition of proliferation and autophagic cell death. The MC50 values for SBA-15 loaded with isoxanthohumol were over 300 µg/mL in all cases investigated.} }