@Article{IPB-2414, author = {Wessjohann, L. and Wild, H.}, title = {{Excellent Aldehyde and Ketone Selectivity in Chromium(II)-Mediated Reformatsky Reactions}}, year = {1997}, pages = {731-733}, journal = {Synlett}, doi = {10.1055/s-1997-3239}, volume = {1997}, abstract = {The chromium Reformatsky reaction allows the highly chemoselective addition of ester enolates to aldehydes or methyl ketones at room temperature. Aldehyde selectivities of ≥ 50:1 vs. methyl ketones and ≥ 200:1 vs. larger ketones and other electrophiles can be achieved in most cases. Methyl ketones are preferred with similar effectivity against higher ketones. Effects of solvents, lithium iodide and substituents are discussed.} }