@Article{IPB-2400, author = {Bini Araba, A. and Ur Rehman, N. and Al-Araimi, A. and Al-Hashmi, S. and Al-Shidhani, S. and Csuk, R. and Hussain, H. and Al-Harrasi, A. and Zadjali, F.}, title = {{New derivatives of 11-keto-β-boswellic acid (KBA) induce apoptosis in breast and prostate cancers cells}}, year = {2019}, journal = {Nat Prod Res}, doi = {10.1080/14786419.2019.1593165}, url = {https://dx.doi.org/10.1080/14786419.2019.1593165}, abstract = {A series of new 11-keto-β-boswellic acid were partially-synthesized by modifying the hydroxyl and carboxylic acid functional groups of ring A. The structures of the new analogs were confirmed by detailed spectral data analysis. Compounds 4, 5 and 9 exhibited potent anti-cancer results against two human tumor cancer cell lines having IC50 value of MCF-7 (breast) and LNCaP (prostate): 123.6, 9.6 and 88.94 μM and 9.6, 44.12 and 12.03 μM, respectively. Additionally, a maximum nuclear fragmentation was observed for 4 (78.44%) in AKBA treated cells after 24 hr followed by 5 and 9 with (74.25 and 66.9% respectively). This study suggests that the presence of hydrazone functionality (4 and 9) has effectively improved the potency of AKBA. Interestingly, compound 5 with a lost carboxylic acid group of ring A showed comparable potent activity. Highly selective AKBA requires further modification to improve its bioavailability and solubility inside the cancer cells.} }