@Article{IPB-1770, author = {Guseman, J. M. and Hellmuth, A. and Lanctot, A. and Feldman, T. P. and Moss, B. L. and Klavins, E. and Calderón Villalobos, L. I. A. and Nemhauser, J. L.}, title = {{Auxin-induced degradation dynamics set the pace for lateral root development}}, year = {2015}, pages = {1-5}, journal = {Development}, doi = {10.1242/dev.117234}, url = {http://dev.biologists.org/content/early/2015/01/29/dev.117234.abstract?sid=44c8748f-9cc2-4f71-93df-bfbc96e0a0c2}, volume = {142}, abstract = {Auxin elicits diverse cell behaviors through a simple nuclear signaling pathway initiated by degradation of Aux/IAA co-repressors. Our previous work revealed that members of the large Arabidopsis Aux/IAA family exhibit a range of degradation rates in synthetic contexts. However, it remained an unresolved issue whether differences in Aux/IAA turnover rates played a significant role in plant responses to auxin. Here, we use the well-established model of lateral root development to directly test the hypothesis that the rate of auxin-induced Aux/IAA turnover sets the pace for auxin-regulated developmental events. We did this by generating transgenic plants expressing degradation rate variants of IAA14, a crucial determinant of lateral root initiation. Progression through the well-established stages of lateral root development was strongly correlated with the engineered rates of IAA14 turnover, leading to the conclusion that Aux/IAAs are auxin-initiated timers that synchronize developmental transitions} }