@Article{IPB-1149, author = {Abel, S.}, title = {{Auxin is surfacing}}, year = {2007}, pages = {380 - 384}, journal = {ACS Chemical Biology}, url = {http://pubs.acs.org/doi/full/10.1021/cb7001158}, volume = {2}, abstract = { Indole-3-acetic acid (IAA or auxin) is essential throughout the life cycle of a plant. It controls diverse cellular processes, including gene expression. The hormone is perceived by a ubiquitin protein ligase (E3) and triggers the rapid destruction of repressors, called Aux/IAA proteins. The first structural model of a plant hormone receptor illustrates how auxin promotes Aux/IAA substrate recruitment by extending the hydrophobic protein-interaction surface. This work establishes a novel mechanism of E3 regulation by small molecules and promises a novel strategy for the treatment of human disorders associated with defective ubiquitin-dependent proteolysis.} }