Aktive Filter
Autor Nach Häufigkeit alphabetisch sortiert: Haack, M
Autor Nach Häufigkeit alphabetisch sortiert: Wessjohann, L.A
Autor Nach Häufigkeit alphabetisch sortiert: Wessjohann, L
Autor Nach Häufigkeit alphabetisch sortiert: Sabo, T. J
Autor Nach Häufigkeit alphabetisch sortiert: Pantelić, N.
Alle Filter entfernen
Suchfilter
- Typ der Publikation
- Publikation (3)
- Erscheinungsjahr
- Journal / Buchreihe / Preprint-Server Nach Häufigkeit alphabetisch sortiert
- J. Serb. Chem. Soc. (1)
- Metals (1)
- Polyhedron (1)
- Autor Nach Häufigkeit alphabetisch sortiert
- Kaluđerović, G. N. (14)
- Wessjohann, L. A. (14)
- Frolov, A. (9)
- Pahnke, J. (6)
- Krajnović, T. (4)
- Maksimović-Ivanić, D. (4)
- Mijatović, S. (4)
- Zmejkovski, B. B. (4)
- Drača, D. (3)
- Farag, M. A. (3)
- Morgan, I. (3)
- Pantelić, N. (3)
- Porzel, A. (3)
- Sabo, T. J. (3)
- Saoud, M. (3)
- Arnold, N. (2)
- Bilova, T. (2)
- Gómez-Ruiz, S. (2)
- Ihling, C. (2)
- Leonova, T. (2)
- Lübken, T. (2)
- Medvedev, S. (2)
- Smolikova, G. (2)
- Stanojković, T. P. (2)
- Stefan, S. M. (2)
- Westermann, B. (2)
- Žižak, ?. (2)
- Adem, A. A. (1)
- Aleksis, R. (1)
- Aranđelović, S. (1)
- Ashmawy, A. M. (1)
- Balarynová, J. (1)
- Banjac, N. R. (1)
- Barroso, S. (1)
- Bascuñana, P. (1)
- Bednář, P. (1)
- Belete, A. (1)
- Bernard, J. (1)
- Bette, E. (1)
- Biverstål, H. (1)
- Božić, B. (1)
- Brandal, P. (1)
- Brandt, W. (1)
- Brito, M. A. (1)
- Calhorda, M. J. (1)
- Cechová, M. Z. (1)
- Chantzeva, V. (1)
- Cherepanov, I. (1)
- Cherevatskaya, M. (1)
- Choucry, M. A. (1)
- Coelho, A. M. (1)
- Correia-Neves, M. (1)
- Denkert, A. (1)
- Dias, C. N. (1)
- Didio, A. (1)
- Dimitrić Marković, J. (1)
- Dimić, D. (1)
- Ditfe, T. (1)
- Dojčinović, B. (1)
- Dubakova, P. S. (1)
- Dunđerović, D. (1)
- Eeg Emblem, K. (1)
- Ehrlich, A. (1)
- Eichhorn, T. (1)
- El-Kersh, D. M. (1)
- El-Seedi, H. (1)
- Erofeeva, N. (1)
- Fayek, N. M. (1)
- Gebre-Mariam, T. (1)
- Gladchuk, A. S. (1)
- Glushchenko, A. S. (1)
- Gorbach, D. (1)
- Grgurić-Šipka, S. (1)
- Grishina, T. (1)
- Gzgzyan, A. M. (1)
- Hald, J. K. (1)
- Hartz, A. M. (1)
- Heiss, A. G. (1)
- Hey-Hawkins, E. (1)
- Hoehenwarter, W. (1)
- Huang, M. L.-H. (1)
- Jansson, P. J. (1)
- Jaudzems, K. (1)
- Jeftić, V. V. (1)
- Kachlmeier, A. (1)
- Kalganova, N. (1)
- Keltsieva, O. A. (1)
- Khlestkina, E. (1)
- Klčová, B. (1)
- Kobrlová, L. (1)
- Kolbe, F. (1)
- Krasnov, K. A. (1)
- Krejčí, P. (1)
- Krohn, M. (1)
- Kropf, M. (1)
- Krylova, E. (1)
- Kufka, R. (1)
- Kysil, E. V. (1)
- Lapina, N. (1)
- Latysheva, A. (1)
Zeige Ergebnisse 1 bis 3 von 3.
Pantelić, N.; Zmejkovski, B. B.; Marković, D. D.; Vujić, J. M.; Stanojković, T. P.; Sabo, T. J.; Kaluđerović, G. N.; Synthesis, Characterization, and Cytotoxicity of a Novel Gold(III) Complex with O,O′-Diethyl Ester of Ethylenediamine-N,N′-Di-2-(4-Methyl)Pentanoic Acid Metals 6, 226, (2016) DOI: 10.3390/met6090226
A novel gold(III) complex, [AuCl2{(S,S)-Et2eddl}]PF6, ((S,S)-Et2eddl = O,O′-diethyl ester of ethylenediamine-N,N′-di-2-(4-methyl)pentanoic acid) was synthesized and characterized by IR, 1D (1H and 13C), and 2D (H,H-COSY and H,H-NOESY) NMR spectroscopy, mass spectrometry, and elemental analysis. Density functional theory calculations confirmed that (R,R)-N,N′ diastereoisomer was energetically the most stable isomer. In vitro antitumor action of ligand precursor [(S,S)-H2Et2eddl]Cl2 and corresponding gold(III) complex was determined against tumor cell lines: human adenocarcinoma (HeLa), human colon carcinoma (LS174), human breast cancer (MCF7), non-small cell lung carcinoma cell line (A549), and non-cancerous cell line human embryonic lung fibroblast (MRC-5) using microculture tetrazolium test (MTT) assay. The results indicate that both ligand precursor and gold(III) complex have showed very good to moderate cytotoxic activity against all tested malignant cell lines. The highest activity was expressed by [AuCl2{(S,S)-Et2eddl}]PF6 against the LS174 cells, with IC50 value of 7.4 ± 1.2 µM.
Pantelić, N.; Zmejkovski, B. B.; Stanojković, T. P.; Jeftić, V. V.; Radić, G. P.; Trifunović, S. R.; Kaluđerović, G. N.; Sabo, T. J.; Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N’-di-2-propanoate dihydrochloride esters J. Serb. Chem. Soc. 79, 649-658, (2014) DOI: 10.2298/JSC130512022P
A novel (S,S)-R2eddip ester, O,O′-diisopentyl-(S,S)-ethylenediamine-N,N′-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, 1H- and 13C-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R2eddip esters, dialkyl (S,S)-ethylenediamine-N,N′-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1–3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50(Fem-x) value of 1.51±0.09 μM.
Zmejkovski, B. B.; Savić, A.; Poljarević, J.; Pantelić, N.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S.; Kaluđerović, G. N.; Sabo, T. J.; Synthesis, characterization and in vitro antitumor activity of new palladium(II) complexes with (S,S)-R2edda-type esters Polyhedron 80, 106-111, (2014) DOI: 10.1016/j.poly.2014.02.026
Six palladium(II) complexes with (S,S)-R2edda-type esters ((S,S)-R2edda-type: (S,S)-eddch = (S,S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl)propanoate, R = Me, Et, n-Pr, 1–3; (S,S)-pddch = (S,S)-propylenediamine-N,N′-di-2-(3-cyclohexyl)propanoate, R = Et, n-Pr, 4, 5; and (S,S)-eddip = (S,S)-ethylenediamne-N,N′-di-2-propanoate, R = i-Am, 6) were synthesized, characterized by IR, NMR spectroscopy, ESI-MS and elemental analysis. DFT calculations indicate that in case of 1–4, the most stable isomers are with (S,S)- and (R,S)-configuration of nitrogen atoms, but for complex 6 (R,R)- and (R,S)-N,N′-configured isomers. Furthermore, complex 5 was obtained as (S,S)-N,N′ configured isomer. Cytotoxicity study was performed against human cervical adenocarcinoma (HeLa), human alveolar basal adenocarcinoma (A549) and non-cancerous human fetal lung fibroblast (MRC-5) cell lines using colorimetric MTT assay. From the investigated palladium(II) complexes 2, 3 and 5 exhibited highest cytotoxic potential against HeLa (IC50: 28.5 ± 3.9, 29.5 ± 1.3 and 34.3 ± 3.2, respectively).
