Aktive Filter
Autor Nach Häufigkeit alphabetisch sortiert: Haack, M
Autor Nach Häufigkeit alphabetisch sortiert: Wessjohann, L.A
Autor Nach Häufigkeit alphabetisch sortiert: Martins, A. M
Autor Nach Häufigkeit alphabetisch sortiert: Leal, I.C.R
Autor Nach Häufigkeit alphabetisch sortiert: Radulović, S.
Alle Filter entfernen
Suchfilter
- Typ der Publikation
- Publikation (1)
- Erscheinungsjahr
- 2014 (1)
- Journal / Buchreihe / Preprint-Server Nach Häufigkeit alphabetisch sortiert
- Polyhedron (1)
- Autor Nach Häufigkeit alphabetisch sortiert
- Kaluđerović, G. N. (14)
- Wessjohann, L. A. (14)
- Frolov, A. (10)
- Pahnke, J. (6)
- Krajnović, T. (4)
- Maksimović-Ivanić, D. (4)
- Mijatović, S. (4)
- Zmejkovski, B. B. (4)
- Drača, D. (3)
- Farag, M. A. (3)
- Morgan, I. (3)
- Pantelić, N. (3)
- Porzel, A. (3)
- Sabo, T. J. (3)
- Saoud, M. (3)
- Arnold, N. (2)
- Bilova, T. (2)
- Gómez-Ruiz, S. (2)
- Ihling, C. (2)
- Leonova, T. (2)
- Lübken, T. (2)
- Medvedev, S. (2)
- Smolikova, G. (2)
- Stanojković, T. P. (2)
- Stefan, S. M. (2)
- Westermann, B. (2)
- Žižak, ?. (2)
- Adem, A. A. (1)
- Aleksis, R. (1)
- Aranđelović, S. (1)
- Ashmawy, A. M. (1)
- Balarynová, J. (1)
- Banjac, N. R. (1)
- Barroso, S. (1)
- Bascuñana, P. (1)
- Bednář, P. (1)
- Belete, A. (1)
- Bernard, J. (1)
- Bette, E. (1)
- Biverstål, H. (1)
- Blüher, M. (1)
- Božić, B. (1)
- Brandal, P. (1)
- Brandt, W. (1)
- Brito, M. A. (1)
- Calhorda, M. J. (1)
- Cechová, M. Z. (1)
- Chantzeva, V. (1)
- Cherepanov, I. (1)
- Cherevatskaya, M. (1)
- Choucry, M. A. (1)
- Coelho, A. M. (1)
- Correia-Neves, M. (1)
- Denkert, A. (1)
- Dias, C. N. (1)
- Didio, A. (1)
- Dimitrić Marković, J. (1)
- Dimić, D. (1)
- Ditfe, T. (1)
- Dojčinović, B. (1)
- Dubakova, P. S. (1)
- Dunđerović, D. (1)
- Eeg Emblem, K. (1)
- Ehrlich, A. (1)
- Eichhorn, T. (1)
- El-Kersh, D. M. (1)
- El-Seedi, H. (1)
- Erofeeva, N. (1)
- Fayek, N. M. (1)
- Gebre-Mariam, T. (1)
- Gladchuk, A. S. (1)
- Glushchenko, A. S. (1)
- Gorbach, D. (1)
- Greifenhagen, U. (1)
- Grgurić-Šipka, S. (1)
- Grishina, T. (1)
- Gzgzyan, A. M. (1)
- Hald, J. K. (1)
- Hartz, A. M. (1)
- Heiss, A. G. (1)
- Hey-Hawkins, E. (1)
- Hoehenwarter, W. (1)
- Hoffmann, R. (1)
- Huang, M. L.-H. (1)
- Jansson, P. J. (1)
- Jaudzems, K. (1)
- Jeftić, V. V. (1)
- Kachlmeier, A. (1)
- Kalganova, N. (1)
- Keltsieva, O. A. (1)
- Khlestkina, E. (1)
- Klčová, B. (1)
- Kobrlová, L. (1)
- Kolbe, F. (1)
- Krasnov, K. A. (1)
- Krejčí, P. (1)
- Krohn, M. (1)
- Kropf, M. (1)
- Krylova, E. (1)
- Kufka, R. (1)
Zeige Ergebnisse 1 bis 1 von 1.
Zmejkovski, B. B.; Savić, A.; Poljarević, J.; Pantelić, N.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S.; Kaluđerović, G. N.; Sabo, T. J.; Synthesis, characterization and in vitro antitumor activity of new palladium(II) complexes with (S,S)-R2edda-type esters Polyhedron 80, 106-111, (2014) DOI: 10.1016/j.poly.2014.02.026
Six palladium(II) complexes with (S,S)-R2edda-type esters ((S,S)-R2edda-type: (S,S)-eddch = (S,S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl)propanoate, R = Me, Et, n-Pr, 1–3; (S,S)-pddch = (S,S)-propylenediamine-N,N′-di-2-(3-cyclohexyl)propanoate, R = Et, n-Pr, 4, 5; and (S,S)-eddip = (S,S)-ethylenediamne-N,N′-di-2-propanoate, R = i-Am, 6) were synthesized, characterized by IR, NMR spectroscopy, ESI-MS and elemental analysis. DFT calculations indicate that in case of 1–4, the most stable isomers are with (S,S)- and (R,S)-configuration of nitrogen atoms, but for complex 6 (R,R)- and (R,S)-N,N′-configured isomers. Furthermore, complex 5 was obtained as (S,S)-N,N′ configured isomer. Cytotoxicity study was performed against human cervical adenocarcinoma (HeLa), human alveolar basal adenocarcinoma (A549) and non-cancerous human fetal lung fibroblast (MRC-5) cell lines using colorimetric MTT assay. From the investigated palladium(II) complexes 2, 3 and 5 exhibited highest cytotoxic potential against HeLa (IC50: 28.5 ± 3.9, 29.5 ± 1.3 and 34.3 ± 3.2, respectively).