Aktive Filter
Autor Nach Häufigkeit alphabetisch sortiert: Haack, M
Autor Nach Häufigkeit alphabetisch sortiert: Wessjohann, L.A
Autor Nach Häufigkeit alphabetisch sortiert: Martins, A. M
Autor Nach Häufigkeit alphabetisch sortiert: Farag, M. A
Autor Nach Häufigkeit alphabetisch sortiert: Coelho, A. M
Autor Nach Häufigkeit alphabetisch sortiert: Shaaban, S.
Alle Filter entfernen
Suchfilter
- Typ der Publikation
- Publikation (1)
- Erscheinungsjahr
- 2019 (1)
- Journal / Buchreihe / Preprint-Server Nach Häufigkeit alphabetisch sortiert
- Autor Nach Häufigkeit alphabetisch sortiert
- Wessjohann, L. A. (29)
- Frolov, A. (25)
- Kaluđerović, G. N. (19)
- Bilova, T. (11)
- Pahnke, J. (11)
- Grishina, T. (8)
- Maksimović-Ivanić, D. (8)
- Mijatović, S. (8)
- Soboleva, A. (8)
- Franke, K. (7)
- Ihling, C. (7)
- Medvedev, S. (7)
- Porzel, A. (7)
- Smolikova, G. (7)
- Hoehenwarter, W. (6)
- Kim, A. (6)
- Wessjohann, L. (6)
- Brandt, W. (5)
- Farag, M. A. (5)
- Krajnović, T. (5)
- Lukasheva, E. (5)
- Mamontova, T. (5)
- Sinz, A. (5)
- Arnold, N. (4)
- Denkert, A. (4)
- Didio, A. (4)
- Gómez-Ruiz, S. (4)
- Morgan, I. (4)
- Saoud, M. (4)
- Zhukov, V. (4)
- Zmejkovski, B. B. (4)
- Drača, D. (3)
- Keltsieva, O. A. (3)
- Krohn, M. (3)
- Mavropolo-Stolyarenko, G. (3)
- Momčilović, M. (3)
- Osmolovskaya, N. (3)
- Pantelić, N. (3)
- Sabo, T. J. (3)
- Schmidt, H. (3)
- Seliger, B. (3)
- Shumilina, J. (3)
- Tarakhovskaya, E. (3)
- Babakov, V. (2)
- Bensing, C. (2)
- Bobach, C. (2)
- Bulatović, M. Z. (2)
- Dojčinović, B. (2)
- Golić, I. (2)
- Greifenhagen, U. (2)
- Hey-Hawkins, E. (2)
- Hoffmann, R. (2)
- Karonova, T. (2)
- Khlestkina, E. (2)
- Korać, A. (2)
- Krylova, E. (2)
- Lam, Y. T. H. (2)
- Leal, I. C. R. (2)
- Leonova, T. (2)
- Lübken, T. (2)
- Mojić, M. (2)
- Proksch, C. (2)
- Pérez-Quintanilla, D. (2)
- Rennert, R. (2)
- Rizzo, P. (2)
- Stanojković, T. P. (2)
- Stark, P. (2)
- Stefan, S. M. (2)
- Stefanov, V. (2)
- Steinborn, D. (2)
- Strygina, K. (2)
- Sultani, H. (2)
- Tikhonovich, I. (2)
- Vikhnina, M. (2)
- Westermann, B. (2)
- Žižak, ?. (2)
- Abbas, M. (1)
- Abdelwareth, A. (1)
- Abouzid, S. F. (1)
- Adem, A. A. (1)
- Afonin, A. M. (1)
- Akhtemova, G. A. (1)
- Aleksis, R. (1)
- Amthauer, H. (1)
- Apostolova, I. (1)
- Aranđelović, S. (1)
- Ashmawy, A. M. (1)
- Athmer, B. (1)
- Ba, L. A. (1)
- Balarynová, J. (1)
- Balcke, G. U. (1)
- Banjac, N. R. (1)
- Bankin, M. (1)
- Barbosa, G. M. (1)
- Barroso, S. (1)
- Baruah, M. (1)
- Bascuñana, P. (1)
- Becana, M. (1)
- Bednář, P. (1)
- Belete, A. (1)
Zeige Ergebnisse 1 bis 1 von 1.
Shaaban, S.; Ashmawy, A. M.; Negm, A.; Wessjohann, L. A.; Synthesis and biochemical studies of novel organic selenides with increased selectivity for hepatocellular carcinoma and breast adenocarcinoma Eur. J. Med. Chem. 179, 515-526, (2019) DOI: 10.1016/j.ejmech.2019.06.075
Nineteen organoselenides were synthesized and tested for their intrinsic cytotoxicity in hepatocellular carcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines and their corresponding selective cytotoxicity (SI) was estimated using normal lung fibroblast (WI-38) cells. Most of the organic selenides exhibited good anticancer activity, and this was more pronounced in HepG2 cells. Interestingly, the naphthoquinone- (5), thiazol- (12), and the azo-based (13) organic selenides demonstrated promising SI (up to 76). Furthermore, the amine 4c, naphthoquinone 5, and azo-based 13 and 15 organic selenides were able to down-regulate the expression of Bcl-2 and up-regulate the expression levels of IL-2, IL-6 and CD40 in HepG2 cells compared to untreated cells. Moreover, most of the synthesized candidates manifested good free radical-scavenging and GPx-like activities comparable to vitamin C and ebselen. The obtained results suggested that some of the presented organoselenium candidates have promising anti-HepG2 and antioxidant activities.