Aktive Filter
Autor Nach Häufigkeit alphabetisch sortiert: Haack, M
Autor Nach Häufigkeit alphabetisch sortiert: Wessjohann, L.A
Autor Nach Häufigkeit alphabetisch sortiert: Humbeck, K
Autor Nach Häufigkeit alphabetisch sortiert: Lübken, T
Autor Nach Häufigkeit alphabetisch sortiert: Carralero, S.
Alle Filter entfernen
Suchfilter
- Typ der Publikation
- Publikation (1)
- Erscheinungsjahr
- 2016 (1)
- Journal / Buchreihe / Preprint-Server Nach Häufigkeit alphabetisch sortiert
- Dalton Trans. (1)
- Autor Nach Häufigkeit alphabetisch sortiert
- Wessjohann, L. A. (77)
- Frolov, A. (60)
- Kaluđerović, G. N. (39)
- Pahnke, J. (34)
- Wessjohann, L. (23)
- Bilova, T. (20)
- Arnold, N. (19)
- Franke, K. (19)
- Krohn, M. (19)
- Porzel, A. (19)
- Medvedev, S. (15)
- Smolikova, G. (15)
- Soboleva, A. (15)
- Farag, M. A. (14)
- Maksimović-Ivanić, D. (14)
- Mijatović, S. (14)
- Zmejkovski, B. B. (12)
- Brandt, W. (11)
- Morgan, I. (11)
- Saoud, M. (11)
- Grishina, T. (10)
- Rennert, R. (10)
- Ihling, C. (9)
- Leonova, T. (9)
- Lukasheva, E. (9)
- Paarmann, K. (9)
- Seliger, B. (9)
- Hoehenwarter, W. (8)
- Langer, O. (8)
- Sabo, T. J. (8)
- Shumilina, J. (8)
- Balcke, G. U. (7)
- Birkemeyer, C. (7)
- Brüning, T. (7)
- Gómez-Ruiz, S. (7)
- Kim, A. (7)
- Lennicke, C. (7)
- Pantelić, N. (7)
- Tarakhovskaya, E. (7)
- Wanek, T. (7)
- Westermann, B. (7)
- Brackhan, M. (6)
- Dojčinović, B. (6)
- Frolova, N. (6)
- Krajnović, T. (6)
- Mairinger, S. (6)
- Osmolovskaya, N. (6)
- Sinz, A. (6)
- Vikhnina, M. (6)
- Zoufal, V. (6)
- Denkert, A. (5)
- Drača, D. (5)
- Filip, T. (5)
- Greifenhagen, U. (5)
- Hey-Hawkins, E. (5)
- Hussain, H. (5)
- Leal, I. C. R. (5)
- Lichtenfels, R. (5)
- Lübken, T. (5)
- Mamontova, T. (5)
- Mojić, M. (5)
- Möhle, L. (5)
- Paudel, G. (5)
- Rahn, J. (5)
- Sauberer, M. (5)
- Stanek, J. (5)
- Stanojković, T. P. (5)
- Tissier, A. (5)
- Zhukov, V. A. (5)
- Bascuñana, P. (4)
- Didio, A. (4)
- Dube, M. (4)
- Eichhorn, T. (4)
- Gorbach, D. (4)
- Mavropolo-Stolyarenko, G. (4)
- Momčilović, M. (4)
- Schmidt, H. (4)
- Schmidt, J. (4)
- Teichert, A. (4)
- Tikhonovich, I. A. (4)
- Tsarev, A. (4)
- Vogt, T. (4)
- Zhukov, V. (4)
- Babakov, V. (3)
- Bensing, C. (3)
- Bin Ware, I. (3)
- Biverstål, H. (3)
- Bobach, C. (3)
- Brauch, D. (3)
- Bulatović, M. (3)
- Bureiko, K. (3)
- Chantseva, V. (3)
- Davari, M. D. (3)
- Dunđerović, D. (3)
- Eiriz, I. (3)
- Fobofou, S. A. T. (3)
- Fotso, G. W. (3)
- Fröhlich, C. (3)
- Imming, P. (3)
- Kaluđerović, M. R. (3)
Zeige Ergebnisse 1 bis 1 von 1.
Bensing, C.; Mojić, M.; Gómez-Ruiz, S.; Carralero, S.; Dojčinović, B.; Maksimović-Ivanić, D.; Mijatović, S.; Kaluđerović, G. N.; Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph3Sn(CH2)3OH against the A2780 ovarian carcinoma cell line Dalton Trans. 45, 18984-18993, (2016) DOI: 10.1039/C6DT03519A
SBA-15|Sn3, a mesoporous silica-based material (derivative of SBA-15) loaded with an organotin compound Ph3Sn(CH2)3OH (Sn3), possesses improved antitumor potential against the A2780 high-grade serous ovarian carcinoma cell line in comparison to Sn3. It is demonstrated that both the compound and the nanostructured material are internalized by the A2780 cells. A similar mode of action of Sn3 and SBA-15|Sn3 against the A2780 cell line was found. Explicitly, induction of apoptosis, caspase 2, 3, 8 and 9 activation, accumulation of cells in the hypodiploid phase as well as accumulation of ROS were observed. Interestingly, Sn3 loaded in the mesoporous silica-based material needed to reach a concentration 3.5 times lower than the IC50 value of the Sn3 compound, pointing out a higher effect of the SBA-15|Sn3 than Sn3 alone. Clonogenic potential, growth in 3D culture as well as mobility of cells were disturbed in the presence of SBA-15|Sn3. Such behavior could be associated with the suppression of p-38 MAPK. Less profound effect of Sn3 compared to SBA-15|Sn3 could be attributed to a different regulation of p-38 and STAT-3, which are mainly responsible for an appropriate cellular response to diverse stimuli or metastatic properties.