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Quang, D. N.; Wagner, C.; Merzweiler, K.; Abate, D.; Porzel, A.; Schmidt, J.; Arnold, N. Pyrofomins A-D, polyoxygenated sesquiterpenoids from Pyrofomes demidoffii. Fitoterapia 112, 229–232, (2016) DOI: 10.1016/j.fitote.2016.06.004

Pyrofomins A-D, four polyoxygenated sesquiterpenoids have been isolated from the methanolic extract of the fruit bodies of Pyrofomes demidoffii. Their structures are elucidated by IR, HR-FTICR-MS, and 2D NMR spectroscopy. Furthermore, the cedrane carbon skeleton of pyrofomin A (1) is confirmed by X-ray crystallographic analysis. The sesquiterpenoids 1–4 show neither cytotoxicity against KB cells nor antimicrobial activity.

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