Naturstoffe & Metabolomik

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Publikation

Anh, N. T. H.; Tuan, N. V.; Thien, D. D.; Quan, T. D.; Tam, N. T.; Lien, G. T. K.; Franke, K.; Thuy, T. T.; Sung, T. V.; Chemical Constituents of Chirita drakei Nat. Prod. Commun. 12, 563-566, (2017) DOI: 10.1177/1934578X1701200425

Chirita drakei Burtt (now accepted as Primulina drakei (B.L.Burtt) Mich.Möller & A.Weber) is growing on limestone mountain slopes of Ha Long Bay islands in Vietnam. The chemical investigation of the aerial parts of C. drakei led to the isolation and structural elucidation of two new compounds named chiridrakoside A (1) and chiridrakoside B (2) besides twelve known compounds comprising five phenylethanoid glycosides (3–7), two lignans (8, 9), a phenyl propanoid (10), an anthraquinone (11), a furan derivative (12) and two triterpenes (13, 14). All described compounds, except 4, 5 and 11, were obtained for the first time from the genera Chirita or Primulina. The cytotoxic activity of the isolated compounds was evaluated against the four human cancer cell lines KB (mouth epidermal carcinoma), HepG2 (hepatocellular carcinoma), Lu (lung carcinoma) and MCF7 (breast carcinoma). Epoxyconiferyl alcohol (10) exhibited cytotoxic activity against the tested cell lines (IC50 from 46 to 128 μM).

Publikation

Thuy, T. T.; Anh, N. T. H.; Sung, T. V.; Dan, T. K.; Chinh, N. B.; Quang, N.; Franke, K.; Arnold, N.; Wessjohann, L.; Phytochemical study on the plants of the antidrug medication heantos 4: Part 4. Phthalides, fatty acids, oligosaccharide esters and miscellaneous compounds Vietnam J. Chem. 51, 546-550, (2013)

Publikation

Thuy, T. T.; Anh, N. H.; Sung, T. V.; Dan, T. K.; Chinh, N. B.; Quang, N.; Franke, K.; Arnold, N.; Wessjohann, L.; Phytochemical study on the plants of the antidrug medication heantos 4: Part 1. Alkaloids and other nitrogen containing compounds Vietnam J. Chem. 51, 185-189, (2013)

Publikation

Anh, N. T. H.; Thuy, T. T.; Sung, T. V.; Dan, T. K.; Chinh, N. B.; Quang, N.; Franke, K.; Arnold, N.; Wessjohann, L.; Phytochemical study on the plants of the antidrug medication heantos 4: Part 3. Homoisoflavonoid, flavonoid and phenolic compounds Vietnam J. Chem. 51, 358-362, (2013)

Publikation

Anh, N. T. H.; Thuy, T. T.; Sung, T. V.; Dan, T. K.; Chinh, N. B.; Quang, N.; Franke, K.; Arnold, N.; Wessjohann, L.; Phytochemical study on the plants of the antidrug medication heantos 4: Part 2. Terpenoid- and steroid compounds Vietnam J. Chem. 51, 190-194, (2013)

Publikation

Ninh, P. T.; Anh, N. T. H.; Sung, T. V.; Wessjohann, L.; Studies on chemical constituents of the roots of Polygala sp.: II - Further phenylpropanoide sucrose esters Vietnam J. Chem. 45, 518-522, (2007)

Publikation

Thuy, T. T.; Sung, T. V.; Franke, K.; Wessjohann, L.; Study on chemical composition of the seeds of Zizyphus Jujuba Mill var. Spinosa Hu Tap chi Duoc lieu 12, 11-13, (2007)

Publikation

Thuy, T. T.; Sung, T. V.; Franke, K.; Arnold, N.; Wessjohann, L.; Flavonone-C-glycosides from the seeds of Zizyphus Jujuba Mill var. Spinosa Hu Vietnam J. Chem. 1-8, (2007)

Publikation

Anh, N. T. H.; Sung, T. V.; Arnold, N.; Wessjohann, L.; Chemical constituents of Zizyphus sativa Gaertn fruits. Part III - Alkaloids Vietnam J. Chem. 45, 237-240, (2007)

Two alkaloids have been isolated from Z. sativa fruits besides butane-2,3-diol and glycerol. The structures of alkaloids were established as stepharine and 1,2-dimethoxy,5,6,6a,7-tetrahydro-4H-dibenzo-quinoline by using MS, NMR spectroscopic data and by comparison with reported data.

Publikation

Anh, N. T. H.; Sung, T. V.; Wessjohann, L.; Chemical constituents of Zizyphus sativa Gaertn fruits. Part II - Triterpenoid acid Vietnam J. Chem. 45, 110-113, (2007)

Three terpenoid acids have been isolated from an ethyl acetate extract of Z. sativa fruits. Their structures were established as betulinic, oleanolic and maslinic acids by means of MS, NMR spectroscopic data and by comparison with reported data.