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Publikation

Ali, N. A. A.; Wurster, M.; Denkert, A.; Al-Sokari, S. S.; Lindequist, U.; Wessjohann, L.; Cytotoxic and antiphytofungal activity of the essential oils from two artemisia species World J. Pharm. Res. 3, 1350-1354, (2014)

Hydrodistilled essential oils from aerial parts of Artemisia abyssinica Sch.Bip. ex A. Rich, and Artemisia arborescens L. growing in Yemen were screened for their cytotoxic and antiphytofungal properties as well as their chemical compositions. Twenty-seven components were identified in the essential oils and the main components of these species were found to be davanone (42.34%), camphor (22.88%), nerolidol (8.96%), and chamazulene (4.46%), from A. abyssinica oil and artemisia ketone (51.05%), camphor (14.09%), α-bisabolol (12.56%) and α-phellandrene (8.69%) from A. arborescens. At concentration of 50 and 25 μg/mL, A. arborescens oil showed a strong cytotoxic activity with growth inhibition of 95%(±1.6) and 74%(±3.8) (IC50 of 16.91 μg/mL) against HT29 tumor cells (Human colonic adenocarcinoma cells), while A. abyssinica oil exhibited at concentration of 100 and 50 μg/mL growth inhibition of 71.0% (±12.5) and 27.3%(±14.4) (IC50 of 75.42 μg/mL) respectively. Bioautographic assay was used to evaluate the antiphytofungal activity of the oils against Cladosporium cucumerinum.
Publikation

Ali, N. A. A.; Sharopov, F. S.; Al-kaf, A. G.; Hill, G. M.; Arnold, N.; Al-Sokari, S. S.; Setzer, W. N.; Wessjohann, L.; Composition of Essential Oil from Tagetes minuta and its Cytotoxic, Antioxidant and Antimicrobial Activities Nat. Prod. Commun. 9, 265-268, (2014) DOI: 10.1177/1934578X1400900233

The essential oil from the leaves of Tagetes minuta L., growing wild in Yemen, was obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. A total of 28 compounds were identified representing 74.2% of total oil composition. Major components of the essential oil were (Z)-ocimenone (15.9%), (E)-ocimenone (34.8%), (Z)-β-ocimene (8.3%), limonene (2.3%), (Z)-tagetone (1.8%), dihydrotagetone (1.4%) and an unidentified dimethylvinylketone derivative (20.6%). The oil showed moderate cytotoxic activity against MCF-7 breast tumor cells, with an IC50 of 54.7 ± 6.2 μg/mL. In the DPPH radical scavenging assay, T. minuta oil showed potent antiradical activity with an IC50 value of 36 μg/mL. Antimicrobial activity was also investigated on several microorganisms, and the essential oil exhibited high activity against methicillin-resistant Staphylococcus aureus (MRSA) with an inhibition zone of 23 mm. It also exhibited remarkable antifungal activity against Candida albicans with an inhibition zone of 26 mm.
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