@Article{IPB-1305, author = {Kopycki, J. and Schmidt, J. and Abel, S. and Grubb, C. D.}, title = {{Chemoenzymatic synthesis of diverse thiohydroximates from glucosinolate-utilizing enzymes from Helix pomatia and Caldicellulosiruptor saccharolyticus}}, year = {2011}, pages = {1039-1046}, journal = {Biotechnol Lett}, doi = {10.1007/s10529-011-0530-y}, url = {http://www.springerlink.com/content/p4x00m77787534t6/fulltext.pdf}, volume = {33}, abstract = { Thiohydroximates comprise a diverse class of compounds important in both biological and industrial chemistry. Their syntheses are generally limited to simple alkyl and aryl compounds with few stereocenters and a narrow range of functional groups. We hypothesized that sequential action of two recombinant enzymes, a sulfatase from Helix pomatia and a β-O-glucosidase from Caldicellulosiruptor saccharolyticus, on glucosinolates would allow synthesis of thiohydroximates from a structurally broad array of abundant precursors. We report successful synthesis of thiohydroximates of varied chemical classes, including from homochiral compounds of demonstrated biological activity. The chemoenzymatic synthetic route reported here should allow access to many, if not all, of the thiohydroximate core structures of the ~200 known naturally occurring glucosinolates. The enrichment of this group for compounds with possible pharmacological potential is discussed.} } @Article{IPB-701, author = {Wasternack, C. and Stenzel, I. and Hause, B. and Hause, G. and Kutter, C. and Maucher, H. and Neumerkel, J. and Feussner, I. and Miersch, O.}, title = {{The wound response in tomato - Role of jasmonic acid}}, year = {2006}, pages = {297-306 }, journal = {J. Plant Physiol}, doi = {10.1016/j.jplph.2005.10.014}, volume = {163}, }