TY - JOUR ID - 1903 TI - Predictive value of hypoglycin A and methylencyclopropylacetic acid conjugates in a horse with atypical myopathy in comparison to its cograzing partners JO - Equine Vet Educ PY - 2018 SP - 24-28 AU - Bochnia, M. AU - Scheidemann, W. AU - Ziegler, J. AU - Sander, J. AU - Vollstedt, S. AU - Glatter, M. AU - Janzen, N. AU - Terhardt, M. AU - Zeyner, A. VL - 30 UR - http://onlinelibrary.wiley.com/journal/10.1001/(ISSN)2042-3292 DO - 10.1111/eve.12596 AB - Hypoglycin A (HGA) was detected in blood and urine of a horse suffering from atypical myopathy (AM; Day 2, serum, 8290 μg/l; urine: Day 1, 574, Day 2, 742 μg/l) and in its cograzing partners with a high variability (46–1570 μg/l serum). Over the period of disease, the level of the toxic metabolites (methylencyclopropylacetic acid [MCPA]-conjugates) increased in body fluids of the AM horse (MCPA-carnitine: Day 2, 0.246, Day 3, 0.581 μmol/l serum; MCPA-carnitine: Day 2, 0.621, Day 3, 0.884 μmol/mmol creatinine in urine) and HGA decreased rapidly (Day 3, 2430 μg/l serum). In cograzing horses MCPA-conjugates were not detected. HGA in seeds ranged from 268 to 367 μg/g. Although HGA was present in body fluids of healthy cograzing horses, MCPA-conjugates were not detectable, in contrast to the AM horse. Therefore, increasing concentrations of MCPA-conjugates are supposed to be linked with the onset of AM and both parameters seem to indicate the clinical stage of disease. However, detection of HGA in body fluids of cograzing horses might be a promising step in preventing the disease. A2 - C1 - Molecular Signal Processing ER - TY - JOUR ID - 831 TI - Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions JO - Biol. Chem PY - 2007 SP - 145-153 AU - Schilling, S. AU - Stenzel, I. AU - von Bohlen, A. AU - Wermann, M. AU - Schulz, K. AU - Demuth, H.-U. AU - Wasternack, C. VL - 388 UR - DO - 10.1515/BC.2007.016 AB - A2 - C1 - Molecular Signal Processing ER -