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- Breves, G. (1)
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Krägeloh, T.; Cavalleri, J. M. V.; Ziegler, J.; Sander, J.; Terhardt, M.; Breves, G.; Cehak, A. Identification of hypoglycin A binding adsorbents as potential preventive measures in co-grazers of atypical myopathy affected horses Equine Vet J 50, 220-227, (2018) DOI: 10.1111/evj.12723
BackgroundIntestinal absorption of hypoglycin A
(HGA) and its metabolism are considered major prerequisites for atypical
myopathy (AM). The increasing incidence and the high mortality rate of
AM urgently necessitate new therapeutic and/or preventative
approaches.ObjectivesTo identify a substance for oral administration
capable of binding HGA in the intestinal lumen and effectively reducing
the intestinal absorption of the toxin.Study designExperimental in vitro
study.MethodsSubstances commonly used in equine practice (activated
charcoal composition, di‐tri‐octahedral smectite, mineral oil and
activated charcoal) were tested for their binding capacity for HGA using
an in vitro incubation method. The substance most effective in binding
HGA was subsequently tested for its potential to reduce intestinal HGA
absorption. Jejunal tissues of 6 horses were incubated in Ussing
chambers to determine mucosal uptake, tissue accumulation, and serosal
release of HGA in the presence and absence of the target substance.
Potential intestinal metabolism in methylenecyclopropyl acetic acid
(MCPA)‐conjugates was investigated by analysing their concentrations in
samples from the Ussing chambers.ResultsActivated charcoal composition
and activated charcoal were identified as potent HGA binding substances
with dose and pH dependent binding capacity. There was no evidence of
intestinal HGA metabolism.Main limitationsBinding capacity of adsorbents
was tested in vitro using aqueous solutions, and in vivo factors such
as transit time and composition of intestinal content, may affect
adsorption capacity after oral administration.ConclusionsFor the first
time, this study identifies substances capable of reducing HGA
intestinal absorption. This might have major implications as a
preventive measure in cograzers of AM affected horses but also in horses
at an early stage of intoxication.