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Dorka, R.; Miersch, O.; Hause, B.; Weik, P.; Wasternack, C. Chronobiologische Phänomene und Jasmonatgehalt bei <i>Viscum album</i> L. (Scheer, R.; Bauer, R.; Bekker, A.; Berg, P. A.; Fintelmann, V.). KVC-Verlag Essen 49-56, (2009) ISBN: 978-3-933351-82

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Publikation

Abel, S. Auxin is surfacing ACS Chemical Biology 2, 380 - 384, (2007)

Indole-3-acetic acid (IAA or auxin) is essential throughout the life cycle of a plant. It controls diverse cellular processes, including gene expression. The hormone is perceived by a ubiquitin protein ligase (E3) and triggers the rapid destruction of repressors, called Aux/IAA proteins. The first structural model of a plant hormone receptor illustrates how auxin promotes Aux/IAA substrate recruitment by extending the hydrophobic protein-interaction surface. This work establishes a novel mechanism of E3 regulation by small molecules and promises a novel strategy for the treatment of human disorders associated with defective ubiquitin-dependent proteolysis.
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