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Publikationen - Molekulare Signalverarbeitung

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Publikation

Wasternack, C. Sulfation switch in the shade Nat Plants 6, 186-187, (2020) DOI: 10.1038/s41477-020-0620-8

Plants adjust the balance between growth and defence using photoreceptors and jasmonates. Levels of active jasmonates are reduced in a phytochrome B-dependent manner by upregulation of a 12-hydroxyjasmonate sulfotransferase, leading to increase in shade avoidance and decrease in defence.
Publikation

Zhang, W.; Ito, H.; Quint, M.; Huang, H.; Noël, L.D.; Gray, W.M. Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex Proc Natl Acad Sci 105, 8470-8475, (2008) DOI: 10.1073/pnas.0804144105

SKP1-Cullin1-F-box protein (SCF) ubiquitin-ligases regulate numerous aspects of eukaryotic growth and development. Cullin-Associated and Neddylation-Dissociated (CAND1) modulates SCF function through its interactions with the CUL1 subunit. Although biochemical studies with human CAND1 suggested that CAND1 plays a negative regulatory role by sequestering CUL1 and preventing SCF complex assembly, genetic studies in Arabidopsis have shown that cand1 mutants exhibit reduced SCF activity, demonstrating that CAND1 is required for optimal SCF function in vivo. Together, these genetic and biochemical studies have suggested a model of CAND1-mediated cycles of SCF complex assembly and disassembly. Here, using the SCFTIR1 complex of the Arabidopsis auxin response pathway, we test the SCF cycling model with Arabidopsis mutant derivatives of CAND1 and CUL1 that have opposing effects on the CAND1CUL1 interaction. We find that the disruption of the CAND1CUL1 interaction results in an increased abundance of assembled SCFTIR1 complex. In contrast, stabilization of the CAND1CUL1 interaction diminishes SCFTIR1 complex abundance. The fact that both decreased and increased CAND1CUL1 interactions result in reduced SCFTIR1 activity in vivo strongly supports the hypothesis that CAND1-mediated cycling is required for optimal SCF function.
Publikation

Stenzel, I.; Hause, B.; Proels, R.; Miersch, O.; Oka, M.; Roitsch, T.; Wasternack, C. The AOC promoter of tomato is regulated by developmental and environmental stimuli Phytochemistry 69, 1859-1869, (2008) DOI: 10.1016/j.phytochem.2008.03.007

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Publikation

Wasternack, C.; Feussner, I. Multifunctional enzymes in oxylipin metabolism Chembiochem. 9, 2373-2375, (2008) DOI: 10.1002/cbic.200800582

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Publikation

Schilling, S.; Wasternack, C.; Demuth, H.U. Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution Biol. Chem 389, 983-991, (2008) DOI: 10.1515/BC.2008.111

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Publikation

Brüx, A.; Liu, T-Y.; Krebs, M.; Stierhof, Y.-D.; Lohmann, J.U.; Miersch, O.; Wasternack, C.; Schumacher, K. Reduced V-ATPase Activity in the trans-Golgi Network Causes Oxylipin-Dependent Hypocotyl Growth Inhibition in Arabidopsis The Plant Cell 20, 1088-1100, (2008) DOI: 10.1105/tpc.108.058362

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Publikation

Kienow, L.; Schneider, K.; Bartsch, M.; Stuible, H.-P.; Weng, H.; Miersch, O.; Wasternack, C.; Kombrink, E. Jasmonates meet fatty acids: functional analysis of a new acyl-coenzyme A synthetase family from Arabidopsis thaliana J. Exp. Bot. 59 (2), 403-419, (2008) DOI: 10.1093/jxb/erm325

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Publikation

Gao, X.; Stumpe, M.; Feussner, I.; Kolomiets, M. A novel plastidial lipoxygenase of maize (Zea mays) ZmLOX6 encodes for a fatty acid hydroperoxide lyase and is uniquely regulated by phytohormones and pathogen infection Planta 227, 491-503, (2008) DOI: 10.1007/s00425-007-0634-8

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Publikation

Miersch, O.; Neumerkel, J.; Dippe, M.; Stenzel, I.; Wasternack, C. Hydroxylated jasmonates are commonly occurring metabolites of jasmonic acid and contribute to a partial switch-off in jasmonate signaling New Phytologist 177, 114-127, (2008) DOI: 10.1111/j.1469-8137.2007.02252.x

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