@Article{IPB-2419,
author = {Wessjohann, L.},
title = {{Epothilones: Promising Natural Products with Taxol-Like Activity}},
year = {1997},
pages = {715-718},
journal = {Angew. Chem. Int. Ed.},
doi = {10.1002/anie.199707151},
volume = {36},
abstract = {Antitumor agents possibly better than taxol might be drived from the epothilones (depicted on the right), which likewise bind to microtubules. The epothilones, which were discovered by Höfle et al. and Reichenbach et al., are easier to synthesize and more soluble in polar solvents than taxol. The results of in vivo activity studies are now eagerly awaited. The exceptional importance of these new tubulin stabilizers is reflected in the race for synthetic approaches to these compounds that has already led to the first total syntheses and several partial solutions.}    
}